Seroatlas · Human Serome Atlas

SAP25

Histone deacetylase complex subunit SAP25

Also known as: FLJ00248, SAP25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEE9
Gene: SAP25
Ensembl: ENSG00000205307
Chromosome: 7
Canonical length: 199 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q8TEE9|SAP25
     1  MTPLAPWDPK YEAKAGPRPV WGANCSSGAS FSGRTLCHPS FWPLYEAASG RGLRPVAPAT
    61  GHWNGQQAPP DAGFPVVCCE DVFLSDPLLP RGQRVPLYLS KAPQQMMGSL KLLPPPPIMS
   121  ARVLPRPSPS RGPSTAWLSG PELIALTGLL QMSQGEPRPS SSAVGPPDHT SDPPSPCGSP
   181  SSSQGADLSL PQTPDTHCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAP25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

spleen: 55 nTPM
ovary: 32 nTPM
testis: 29 nTPM
bone marrow: 27 nTPM
lymph node: 27 nTPM
small intestine: 23 nTPM

Single-cell type

microglia: 34 nCPM
renal collecting duct intercalated cells: 15 nCPM
astrocytes: 11 nCPM
podocytes: 9.5 nCPM
bergmann glia: 9 nCPM
oligodendrocytes: 8.3 nCPM

Immune cell

neutrophil: 1.1 nTPM
basophil: 0.9 nTPM
intermediate monocyte: 0.5 nTPM
plasmacytoid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM

Brain region

white matter: 25 nTPM
cerebral cortex: 21 nTPM
medulla oblongata: 20 nTPM
thalamus: 19 nTPM
basal ganglia: 17 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0.09
gnomAD missense Z: 0.36
DepMap mean gene effect: -0.02
DepMap dependency class: selective

OntologyGO

Biological processes

regulation of DNA-templated transcription

Cellular components

Protein domainsUniProt · Pfam · InterPro

Histone deacetylase complex subunit SAP25
Histone deacetylase complex subunit SAP25

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAP25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAP25 as an antibody target. Whether an autoantibody or antibody against SAP25 could matter depends on whether native SAP25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAP25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAP25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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