DACH1

Protein identityUniProt · HPA

UniProt accession

Q9UI36

Gene

DACH1

Ensembl

ENSG00000276644

Chromosome

13

Canonical length

758 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

758 residues, UniProt reviewed canonical sequence.

>Q9UI36|DACH1
     1  MAVPAALIPP TQLVPPQPPI STSASSSGTT TSTSSATSSP APSIGPPASS GPTLFRPEPI
    61  ASAAAAAATV TSTGGGGGGG GSGGGGGSSG NGGGGGGGGG GSNCNPNLAA ASNGSGGGGG
   121  GISAGGGVAS STPINASTGS SSSSSSSSSS SSSSSSSSSS SSSCGPLPGK PVYSTPSPVE
   181  NTPQNNECKM VDLRGAKVAS FTVEGCELIC LPQAFDLFLK HLVGGLHTVY TKLKRLEITP
   241  VVCNVEQVRI LRGLGAIQPG VNRCKLISRK DFETLYNDCT NASSRPGRPP KRTQSVTSPE
   301  NSHIMPHSVP GLMSPGIIPP TGLTAAAAAA AAATNAAIAE AMKVKKIKLE AMSNYHASNN
   361  QHGADSENGD MNSSVGSSDG SWDKETLPSS PSQGPQASIT HPRMPGARSL PLSHPLNHLQ
   421  QSHLLPNGLE LPFMMMPHPL IPVSLPPASV TMAMSQMNHL STIANMAAAA QVQSPPSRVE
   481  TSVIKERVPD SPSPAPSLEE GRRPGSHPSS HRSSSVSSSP ARTESSSDRI PVHQNGLSMN
   541  QMLMGLSPNV LPGPKEGDLA GHDMGHESKR MHIEKDETPL STPTARDSLD KLSLTGHGQP
   601  LPPGFPSPFL FPDGLSSIET LLTNIQGLLK VAIDNARAQE KQVQLEKTEL KMDFLREREL
   661  RETLEKQLAM EQKNRAIVQK RLKKEKKAKR KLQEALEFET KRREQAEQTL KQAASTDSLR
   721  VLNDSLTPEI EADRSGGRTD AERTIQDGRL YLKTTVMY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DACH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

19 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.14

gnomAD pLI

1

gnomAD missense Z

2.19

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• development of primary female sexual characteristics
• negative regulation of cell migration
• negative regulation of cell proliferation involved in contact inhibition
• negative regulation of DNA biosynthetic process
• negative regulation of DNA-templated transcription
• negative regulation of fibroblast proliferation
• negative regulation of transcription by competitive promoter binding
• negative regulation of transcription by RNA polymerase II
• regulation of nuclear cell cycle DNA replication
• regulation of transcription by RNA polymerase II
• respiratory gaseous exchange by respiratory system
• suckling behavior
• type B pancreatic cell proliferation

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• DNA-binding transcription repressor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding

Cellular components

• cytosol
• Golgi apparatus
• nuclear speck
• nucleoplasm
• nucleus
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• SKI/SNO/DAC domain
• Putative DNA-binding domain superfamily
• Ski-like, DNA-binding domain superfamily
• Dachshund domain-containing protein
• SKI/SNO/DAC Dachshund homology domain

KeywordsUniProt

• Activator
• Coiled coil
• Developmental protein
• DNA-binding
• Nucleus
• Phosphoprotein
• Repressor
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of DACH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EYA3
• NCOR1
• SIX1
• SIX6
• SMAD3
• SMAD4
• HDAC3
• SIN3A