Seroatlas · Human Serome Atlas

HIP1R

Huntingtin-interacting protein 1-related protein

Also known as: FLJ14000, HIP12, HIP1R_HUMAN, HIP3, ILWEQ, KIAA0655

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75146
Gene
HIP1R
Ensembl
ENSG00000130787
Chromosome
12
Canonical length
1068 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of signal transduction; protein stabilization; and regulation of organelle organization. Located in clathrin-coated vesicle; cytosol; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1068 residues, UniProt reviewed canonical sequence.

>O75146|HIP1R
     1  MNSIKNVPAR VLSRRPGHSL EAEREQFDKT QAISISKAIN TQEAPVKEKH ARRIILGTHH
    61  EKGAFTFWSY AIGLPLPSSS ILSWKFCHVL HKVLRDGHPN VLHDCQRYRS NIREIGDLWG
   121  HLHDRYGQLV NVYTKLLLTK ISFHLKHPQF PAGLEVTDEV LEKAAGTDVN NIFQLTVEMF
   181  DYMDCELKLS ESVFRQLNTA IAVSQMSSGQ CRLAPLIQVI QDCSHLYHYT VKLLFKLHSC
   241  LPADTLQGHR DRFHEQFHSL RNFFRRASDM LYFKRLIQIP RLPEGPPNFL RASALAEHIK
   301  PVVVIPEEAP EDEEPENLIE ISTGPPAGEP VVVADLFDQT FGPPNGSVKD DRDLQIESLK
   361  REVEMLRSEL EKIKLEAQRY IAQLKSQVNA LEGELEEQRK QKQKALVDNE QLRHELAQLR
   421  AAQLEGERSQ GLREEAERKA SATEARYNKL KEKHSELVHV HAELLRKNAD TAKQLTVTQQ
   481  SQEEVARVKE QLAFQVEQVK RESELKLEEK SDQLEKLKRE LEAKAGELAR AQEALSHTEQ
   541  SKSELSSRLD TLSAEKDALS GAVRQREADL LAAQSLVRET EAALSREQQR SSQEQGELQG
   601  RLAERESQEQ GLRQRLLDEQ FAVLRGAAAE AAGILQDAVS KLDDPLHLRC TSSPDYLVSR
   661  AQEALDAVST LEEGHAQYLT SLADASALVA ALTRFSHLAA DTIINGGATS HLAPTDPADR
   721  LIDTCRECGA RALELMGQLQ DQQALRHMQA SLVRTPLQGI LQLGQELKPK SLDVRQEELG
   781  AVVDKEMAAT SAAIEDAVRR IEDMMNQARH ASSGVKLEVN ERILNSCTDL MKAIRLLVTT
   841  STSLQKEIVE SGRGAATQQE FYAKNSRWTE GLISASKAVG WGATQLVEAA DKVVLHTGKY
   901  EELIVCSHEI AASTAQLVAA SKVKANKHSP HLSRLQECSR TVNERAANVV ASTKSGQEQI
   961  EDRDTMDFSG LSLIKLKKQE METQVRVLEL EKTLEAERMR LGELRKQHYV LAGASGSPGE
  1021  EVAIRPSTAP RSVTTKKPPL AQKPSVAPRQ DHQLDKKDGI YPAQLVNY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HIP1R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
78 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 78 nTPM
  • hippocampal formation: 73 nTPM
  • spinal cord: 72 nTPM
  • stomach: 65 nTPM
  • amygdala: 64 nTPM
  • cerebral cortex: 56 nTPM

Single-cell type

  • tuft cells: 311 nCPM
  • oligodendrocyte progenitor cells: 256 nCPM
  • somatotrophs: 168 nCPM
  • thyrotrophs: 159 nCPM
  • renal connecting tubule cells: 128 nCPM
  • renal collecting duct principal cells: 125 nCPM

Immune cell

  • naive B-cell: 11 nTPM
  • memory B-cell: 9.3 nTPM
  • naive CD4 T-cell: 3 nTPM
  • eosinophil: 2.9 nTPM
  • gdT-cell: 2.7 nTPM
  • memory CD8 T-cell: 2.1 nTPM

Brain region

  • white matter: 158 nTPM
  • basal ganglia: 148 nTPM
  • medulla oblongata: 132 nTPM
  • thalamus: 130 nTPM
  • midbrain: 124 nTPM
  • cerebral cortex: 117 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
-0.03
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HIP1R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HIP1R as an antibody target. Whether an autoantibody or antibody against HIP1R could matter depends on whether native HIP1R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HIP1R is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HIP1R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HIP1R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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