DDN
Dendrin
Also known as: DEND_HUMAN, KIAA0749
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O94850
- Gene
- DDN
- Ensembl
- ENSG00000181418
- Chromosome
- 12
- Canonical length
- 711 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in cell projection and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
711 residues, UniProt reviewed canonical sequence.
>O94850|DDN
1 MLDGPLFSEG PDSPRELQDE ESGSCLWVQK SKLLVIEVKT ISCHYSRRAP SRQPMDFQAS
61 HWARGFQNRT CGPRPGSPQP PPRRPWASRV LQEATNWRAG PLAEVRAREQ EKRKAASQER
121 EAKETERKRR KAGGARRSPP GRPRPEPRNA PRVAQLAGLP APLRPERLAP VGRAPRPSAQ
181 PQSDPGSAWA GPWGGRRPGP PSYEAHLLLR GSAGTAPRRR WDRPPPYVAP PSYEGPHRTL
241 GTKRGPGNSQ VPTSSAPAAT PARTDGGRTK KRLDPRIYRD VLGAWGLRQG QGLLGGSPGC
301 GAARARPEPG KGVVEKSLGL AAADLNSGSD SHPQAKATGS AGTEIAPAGS ATAAPCAPHP
361 APRSRHHLKG SREGKEGEQI WFPKCWIPSP KKQPPRHSQT LPRPWAPGGT GWRESLGLGE
421 GAGPETLEGW KATRRAHTLP RSSQGLSRGE GVFVIDATCV VIRSQYVPTP RTQQVQLLPS
481 GVTRVVGDSP SQSKPGKEEG EGATVFPSPC QKRLSSSRLL HQPGGGRGGE AEGGRPGDST
541 LEERTFRILG LPAPEVNLRD APTQPGSPEH QALGPAASGA QGRAEGSEVA VVQRRAGRGW
601 ARTPGPYAGA LREAVSRIRR HTAPDSDTDE AEELSVHSGS SDGSDTEAPG ASWRNERTLP
661 EVGNSSPEED GKTAELSDSV GEILDVISQT EEVLFGVRDI RGTQQGNRKR QLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DDN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
- Highest tissue expression
- 278 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 278 nTPM
- cerebral cortex: 234 nTPM
- amygdala: 218 nTPM
- basal ganglia: 203 nTPM
- hippocampal formation: 183 nTPM
- kidney: 19 nTPM
Single-cell type
- podocytes: 117 nCPM
- brain inhibitory neurons: 9.8 nCPM
- brain excitatory neurons: 8.3 nCPM
- other brain neurons: 2.2 nCPM
- neuroendocrine cells: 1.9 nCPM
- myonuclei: 1.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 408 nTPM
- amygdala: 358 nTPM
- hippocampal formation: 308 nTPM
- basal ganglia: 287 nTPM
- white matter: 161 nTPM
- thalamus: 41 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.48
- gnomAD pLI
- 0.36
- gnomAD missense Z
- 0.53
- DepMap mean gene effect
- -0.32
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Dendrin
- Nephrin and CD2AP-binding protein, Dendrin
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of DDN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DDN as an antibody target. Whether an autoantibody or antibody against DDN could matter depends on whether native DDN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DDN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DDN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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