Seroatlas · Human Serome Atlas

CD2

T-cell surface antigen CD2

Also known as: CD2_HUMAN, SRBC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P06729
Gene: CD2
Ensembl: ENSG00000116824
Chromosome: 1
Canonical length: 351 aa
Protein class: CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>P06729|CD2
     1  MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE
    61  KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK
   121  IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL
   181  SAKFKCTAGN KVSKESSVEP VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ
   241  RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP
   301  GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 233 nTPM

Expression across tissuesHPA

Tissue

thymus: 233 nTPM
lymph node: 112 nTPM
tonsil: 74 nTPM
appendix: 48 nTPM
spleen: 42 nTPM
small intestine: 27 nTPM

Single-cell type

t-cells: 525 nCPM
nk-cells: 142 nCPM
innate lymphoid cells: 132 nCPM
thymocytes: 42 nCPM
cdc: 31 nCPM
late primary spermatocytes: 22 nCPM

Immune cell

NK-cell: 1,111 nTPM
memory CD8 T-cell: 714 nTPM
T-reg: 657 nTPM
memory CD4 T-cell: 612 nTPM
total PBMC: 565 nTPM
naive CD8 T-cell: 488 nTPM

Brain region

medulla oblongata: 2.3 nTPM
white matter: 1.5 nTPM
thalamus: 1.3 nTPM
spinal cord: 1.2 nTPM
pons: 1.1 nTPM
choroid plexus: 1 nTPM

ReferencesPubMed · IEDB

Publications for CD2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

5 publications

Distinct regulatory roles of lymphocyte costimulatory pathways on T helper type-2 mediated autoimmune disease.
1996 · J Exp Med · RCR 1.1 · 54 citations
Reconstitution of peripheral blood lymphocyte subsets in the long-term disease-free survivors of patients with acute myeloblastic leukemia.
1998 · Leukemia · RCR 0.6 · 24 citations
The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28.
2000 · J Interferon Cytokine Res · RCR 0.5 · 31 citations
Anti-CD3 and anti-CD2-induced T-cell activation in primary Sjögren's syndrome.
1989 · Clin Exp Rheumatol · RCR 0.1 · 3 citations
A human monoclonal antibody to a human self-antigen, CD2 derived from human peripheral blood lymphocytes engrafted in SCID mice.
1995 · Hybridoma · RCR 0.1 · 3 citations

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.47
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD2 as an antibody target. Whether an autoantibody or antibody against CD2 could matter depends on whether native CD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD2 is annotated at the cell surface, where native CD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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