Seroatlas · Human Serome Atlas

RPL36AL

Ribosomal protein eL42-like

Also known as: RL36L_HUMAN, RPL36A, RPL36AP42

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969Q0
Gene
RPL36AL
Ensembl
ENSG00000165502
Chromosome
14
Canonical length
106 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Plasma membrane,Cytosol

OverviewNCBI Gene

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. This gene and the human gene officially named ribosomal protein L36a (RPL36A) encode nearly identical proteins; however, they are distinct genes. Although the name of this gene has been referred to as ribosomal protein L36a (RPL36A), its official name is ribosomal protein L36a-like (RPL36AL). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>Q969Q0|RPL36AL
     1  MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGRRR YDRKQSGYGG QTKPIFRKKA
    61  KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK GQVIQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL36AL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
690 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 690 nTPM
  • ovary: 559 nTPM
  • epididymis: 465 nTPM
  • blood vessel: 458 nTPM
  • skeletal muscle: 418 nTPM
  • stomach: 394 nTPM

Single-cell type

  • esophageal apical cells: 2,929 nCPM
  • epididymal principal cells: 1,541 nCPM
  • esophageal suprabasal cells: 1,453 nCPM
  • pancreatic acinar cells: 1,411 nCPM
  • epididymal efferent duct absorptive cells: 1,338 nCPM
  • mast cells: 1,284 nCPM

Immune cell

  • total PBMC: 1,508 nTPM
  • basophil: 1,315 nTPM
  • MAIT T-cell: 1,116 nTPM
  • T-reg: 1,100 nTPM
  • memory CD4 T-cell: 1,074 nTPM
  • memory CD8 T-cell: 1,041 nTPM

Brain region

  • medulla oblongata: 114 nTPM
  • white matter: 113 nTPM
  • hypothalamus: 112 nTPM
  • spinal cord: 110 nTPM
  • thalamus: 107 nTPM
  • basal ganglia: 104 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.68
gnomAD pLI
0.05
gnomAD missense Z
1.14
DepMap mean gene effect
-0.69
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL36AL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL36AL as an antibody target. Whether an autoantibody or antibody against RPL36AL could matter depends on whether native RPL36AL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL36AL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL36AL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL36AL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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