Seroatlas · Human Serome Atlas

ZC3H18

Zinc finger CCCH domain-containing protein 18

Also known as: NHN1, ZCH18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VM9
Gene: ZC3H18
Ensembl: ENSG00000158545
Chromosome: 16
Canonical length: 953 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in RNA destabilization. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

953 residues, UniProt reviewed canonical sequence.

>Q86VM9|ZC3H18
     1  MDVAESPERD PHSPEDEEQP QGLSDDDILR DSGSDQDLDG AGVRASDLED EESAARGPSQ
    61  EEEDNHSDEE DRASEPKSQD QDSEVNELSR GPTSSPCEEE GDEGEEDRTS DLRDEASSVT
   121  RELDEHELDY DEEVPEEPAP AVQEDEAEKA GAEDDEEKGE GTPREEGKAG VQSVGEKESL
   181  EAAKEKKKED DDGEIDDGEI DDDDLEEGEV KDPSDRKVRP RPTCRFFMKG NCTWGMNCRF
   241  IHPGVNDKGN YSLITKADPF PPNGAPPLGP HPLMPANPWG GPVVDEILPP PPPEPPTESA
   301  WERGLRHAKE VLKKATIRKE QEPDFEEKRF TVTIGEDERE FDKENEVFRD WNSRIPRDVR
   361  DTVLEPYADP YYDYEIERFW RGGQYENFRV QYTETEPYHN YRERERERER ENRQRERERE
   421  RERDRERERR QRERERERER ERDKERQRRK EEWERERAKR DEKDRQHRDR DREKEREKEK
   481  GKPKPRSPQP PSRQAEPPKK EAATTGPQVK RADEWKDPWR RSKSPKKKLG VSVSPSRARR
   541  RRKTSASSAS ASNSSRSSSR SSSYSGSGSS RSRSRSSSYS SYSSRSSRHS SFSGSRSRSR
   601  SFSSSPSPSP TPSPHRPSIR TKGEPAPPPG KAGEKSVKKP APPPAPPQAT KTTAPVPEPT
   661  KPGDPREARR KERPARTPPR RRTLSGSGSG SGSSYSGSSS RSRSLSVSSV SSVSSATSSS
   721  SSAHSVDSED MYADLASPVS SASSRSPAPA QTRKEKGKSK KEDGVKEEKR KRDSSTQPPK
   781  SAKPPAGGKS SQQPSTPQQA PPGQPQQGTF VAHKEIKLTL LNKAADKGSR KRYEPSDKDR
   841  QSPPPAKRPN TSPDRGSRDR KSGGRLGSPK PERQRGQNSK APAAPADRKR QLSPQSKSSS
   901  KVTSVPGKAS DPGAASTKSG KASTLSRREE LLKQLKAVED AIARKRAKIP GKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
bone marrow: 24 nTPM
cerebellum: 22 nTPM
skeletal muscle: 22 nTPM
thymus: 18 nTPM
appendix: 18 nTPM

Single-cell type

neutrophils: 204 nCPM
early spermatids: 116 nCPM
tuft cells: 92 nCPM
monocytes: 88 nCPM
nk-cells: 80 nCPM
erythrocyte progenitors: 73 nCPM

Immune cell

non-classical monocyte: 5.4 nTPM
neutrophil: 3.4 nTPM
T-reg: 3.4 nTPM
NK-cell: 3.1 nTPM
MAIT T-cell: 2.9 nTPM
plasmacytoid DC: 2.8 nTPM

Brain region

cerebellum: 36 nTPM
cerebral cortex: 32 nTPM
white matter: 31 nTPM
hypothalamus: 30 nTPM
basal ganglia: 30 nTPM
amygdala: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.59
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

RNA destabilization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCCH-type
Zinc finger, CCCH-type superfamily
E3 ligase, CCCH-type zinc finger
CCCH-type zinc finger
Zinc finger CCCH-type domain-containing protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3H18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H18 as an antibody target. Whether an autoantibody or antibody against ZC3H18 could matter depends on whether native ZC3H18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...