Seroatlas · Human Serome Atlas

CEBPZ

CCAAT/enhancer-binding protein zeta

Also known as: CBF2, CEBPZ_HUMAN, CTF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03701
Gene
CEBPZ
Ensembl
ENSG00000115816
Chromosome
2
Canonical length
1054 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. [provided by RefSeq, Nov 2020]

Canonical amino-acid sequenceUniProt

1054 residues, UniProt reviewed canonical sequence.

>Q03701|CEBPZ
     1  MAAVKEPLEF HAKRPWRPEE AVEDPDEEDE DNTSEAENGF SLEEVLRLGG TKQDYLMLAT
    61  LDENEEVIDG GKKGAIDDLQ QGELEAFIQN LNLAKYTKAS LVEEDEPAEK ENSSKKEVKI
   121  PKINNKNTAE SQRTSVNKVK NKNRPEPHSD ENGSTTPKVK KDKQNIFEFF ERQTLLLRPG
   181  GKWYDLEYSN EYSLKPQPQD VVSKYKTLAQ KLYQHEINLF KSKTNSQKGA SSTWMKAIVS
   241  SGTLGDRMAA MILLIQDDAV HTLQFVETLV NLVKKKGSKQ QCLMALDTFK ELLITDLLPD
   301  NRKLRIFSQR PFDKLEQLSS GNKDSRDRRL ILWYFEHQLK HLVAEFVQVL ETLSHDTLVT
   361  TKTRALTVAH ELLCNKPEEE KALLVQVVNK LGDPQNRIAT KASHLLETLL CKHPNMKGVV
   421  SGEVERLLFR SNISSKAQYY AICFLNQMAL SHEESELANK LITVYFCFFR TCVKKKDVES
   481  KMLSALLTGV NRAYPYSQTG DDKVREQIDT LFKVLHIVNF NTSVQALMLL FQVMNSQQTI
   541  SDRYYTALYR KMLDPGLMTC SKQAMFLNLV YKSLKADIVL RRVKAFVKRL LQVTCQQMPP
   601  FICGALYLVS EILKAKPGLR SQLDDHPESD DEENFIDAND DEDMEKFTDA DKETEIVKKL
   661  ETEETVPETD VETKKPEVAS WVHFDNLKGG KQLNKYDPFS RNPLFCGAEN TSLWELKKLS
   721  VHFHPSVALF AKTILQGNYI QYSGDPLQDF TLMRFLDRFV YRNPKPHKGK ENTDSVVMQP
   781  KRKHFIKDIR HLPVNSKEFL AKEESQIPVD EVFFHRYYKK VAVKEKQKRD ADEESIEDVD
   841  DEEFEELIDT FEDDNCFSSG KDDMDFAGNV KKRTKGAKDN TLDEDSEGSD DELGNLDDDE
   901  VSLGSMDDEE FAEVDEDGGT FMDVLDDESE SVPELEVHSK VSTKKSKRKG TDDFDFAGSF
   961  QGPRKKKRNL NDSSLFVSAE EFGHLLDENM GSKFDNIGMN AMANKDNASL KQLRWEAERD
  1021  DWLHNRDAKS IIKKKKHFKK KRIKTTQKTK KQRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEBPZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • testis: 36 nTPM
  • skeletal muscle: 36 nTPM
  • bone marrow: 30 nTPM
  • adrenal gland: 26 nTPM
  • liver: 25 nTPM
  • urinary bladder: 25 nTPM

Single-cell type

  • late primary spermatocytes: 502 nCPM
  • early spermatids: 250 nCPM
  • erythrocyte progenitors: 153 nCPM
  • basal keratinocytes: 151 nCPM
  • megakaryocyte-erythroid progenitors: 130 nCPM
  • megakaryocyte progenitors: 128 nCPM

Immune cell

  • basophil: 35 nTPM
  • naive CD4 T-cell: 31 nTPM
  • naive B-cell: 30 nTPM
  • MAIT T-cell: 30 nTPM
  • memory B-cell: 30 nTPM
  • naive CD8 T-cell: 26 nTPM

Brain region

  • cerebellum: 31 nTPM
  • white matter: 27 nTPM
  • choroid plexus: 23 nTPM
  • hypothalamus: 23 nTPM
  • cerebral cortex: 22 nTPM
  • thalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0
gnomAD missense Z
-1.64
DepMap mean gene effect
-1.07
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEBPZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEBPZ as an antibody target. Whether an autoantibody or antibody against CEBPZ could matter depends on whether native CEBPZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEBPZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEBPZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEBPZ. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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