Seroatlas · Human Serome Atlas

NFATC2

Nuclear factor of activated T-cells, cytoplasmic 2

Also known as: NF-ATP, NFAC2_HUMAN, NFAT1, NFATp

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13469
Gene
NFATC2
Ensembl
ENSG00000101096
Chromosome
20
Canonical length
925 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

925 residues, UniProt reviewed canonical sequence.

>Q13469|NFATC2
     1  MNAPERQPQP DGGDAPGHEP GGSPQDELDF SILFDYEYLN PNEEEPNAHK VASPPSGPAY
    61  PDDVLDYGLK PYSPLASLSG EPPGRFGEPD RVGPQKFLSA AKPAGASGLS PRIEITPSHE
   121  LIQAVGPLRM RDAGLLVEQP PLAGVAASPR FTLPVPGFEG YREPLCLSPA SSGSSASFIS
   181  DTFSPYTSPC VSPNNGGPDD LCPQFQNIPA HYSPRTSPIM SPRTSLAEDS CLGRHSPVPR
   241  PASRSSSPGA KRRHSCAEAL VALPPGASPQ RSRSPSPQPS SHVAPQDHGS PAGYPPVAGS
   301  AVIMDALNSL ATDSPCGIPP KMWKTSPDPS PVSAAPSKAG LPRHIYPAVE FLGPCEQGER
   361  RNSAPESILL VPPTWPKPLV PAIPICSIPV TASLPPLEWP LSSQSGSYEL RIEVQPKPHH
   421  RAHYETEGSR GAVKAPTGGH PVVQLHGYME NKPLGLQIFI GTADERILKP HAFYQVHRIT
   481  GKTVTTTSYE KIVGNTKVLE IPLEPKNNMR ATIDCAGILK LRNADIELRK GETDIGRKNT
   541  RVRLVFRVHI PESSGRIVSL QTASNPIECS QRSAHELPMV ERQDTDSCLV YGGQQMILTG
   601  QNFTSESKVV FTEKTTDGQQ IWEMEATVDK DKSQPNMLFV EIPEYRNKHI RTPVKVNFYV
   661  INGKRKRSQP QHFTYHPVPA IKTEPTDEYD PTLICSPTHG GLGSQPYYPQ HPMVAESPSC
   721  LVATMAPCQQ FRTGLSSPDA RYQQQNPAAV LYQRSKSLSP SLLGYQQPAL MAAPLSLADA
   781  HRSVLVHAGS QGQSSALLHP SPTNQQASPV IHYSPTNQQL RCGSHQEFQH IMYCENFAPG
   841  TTRPGPPPVS QGQRLSPGSY PTVIQQQNAT SQRAAKNGPP VSDQKEVLPA GVTIKQEQNL
   901  DQTYLDDVNE IIRKEFSGPP ARNQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFATC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • gallbladder: 16 nTPM
  • lymph node: 15 nTPM
  • tonsil: 13 nTPM
  • choroid plexus: 13 nTPM
  • spleen: 12 nTPM
  • stomach: 10 nTPM

Single-cell type

  • schwann cells: 757 nCPM
  • choroid plexus epithelial cells: 498 nCPM
  • nk-cells: 322 nCPM
  • microglia: 316 nCPM
  • mesothelial cells: 243 nCPM
  • hofbauer cells: 240 nCPM

Immune cell

  • NK-cell: 5.8 nTPM
  • gdT-cell: 5.3 nTPM
  • memory CD8 T-cell: 4.3 nTPM
  • eosinophil: 3.1 nTPM
  • naive CD8 T-cell: 3 nTPM
  • memory CD4 T-cell: 2.9 nTPM

Brain region

  • choroid plexus: 57 nTPM
  • midbrain: 19 nTPM
  • thalamus: 17 nTPM
  • medulla oblongata: 17 nTPM
  • basal ganglia: 14 nTPM
  • pons: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NFATC2.

Disease | AllUniProt

Conditions NFATC2 is implicated in, by any mechanism.

  • Joint contractures, osteochondromas, and B-cell lymphoma (JCOSL) MIM:620232

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
1.64
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFATC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFATC2 as an antibody target. Whether an autoantibody or antibody against NFATC2 could matter depends on whether native NFATC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFATC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFATC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NFATC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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