Seroatlas · Human Serome Atlas

TACC3

Transforming acidic coiled-coil-containing protein 3

Also known as: ERIC-1, ERIC1, maskin, TACC3_HUMAN, Tacc4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6A5
Gene: TACC3
Ensembl: ENSG00000013810
Chromosome: 4
Canonical length: 838 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Mitotic spindle,Centriolar satellite,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

838 residues, UniProt reviewed canonical sequence.

>Q9Y6A5|TACC3
     1  MSLQVLNDKN VSNEKNTENC DFLFSPPEVT GRSSVLRVSQ KENVPPKNLA KAMKVTFQTP
    61  LRDPQTHRIL SPSMASKLEA PFTQDDTLGL ENSHPVWTQK ENQQLIKEVD AKTTHGILQK
   121  PVEADTDLLG DASPAFGSGS SSESGPGALA DLDCSSSSQS PGSSENQMVS PGKVSGSPEQ
   181  AVEENLSSYS LDRRVTPASE TLEDPCRTES QHKAETPHGA EEECKAETPH GAEEECRHGG
   241  VCAPAAVATS PPGAIPKEAC GGAPLQGLPG EALGCPAGVG TPVPADGTQT LTCAHTSAPE
   301  STAPTNHLVA GRAMTLSPQE EVAAGQMASS SRSGPVKLEF DVSDGATSKR APPPRRLGER
   361  SGLKPPLRKA AVRQQKAPQE VEEDDGRSGA GEDPPMPASR GSYHLDWDKM DDPNFIPFGG
   421  DTKSGCSEAQ PPESPETRLG QPAAEQLHAG PATEEPGPCL SQQLHSASAE DTPVVQLAAE
   481  TPTAESKERA LNSASTSLPT SCPGSEPVPT HQQGQPALEL KEESFRDPAE VLGTGAEVDY
   541  LEQFGTSSFK ESALRKQSLY LKFDPLLRDS PGRPVPVATE TSSMHGANET PSGRPREAKL
   601  VEFDFLGALD IPVPGPPPGV PAPGGPPLST GPIVDLLQYS QKDLDAVVKA TQEENRELRS
   661  RCEELHGKNL ELGKIMDRFE EVVYQAMEEV QKQKELSKAE IQKVLKEKDQ LTTDLNSMEK
   721  SFSDLFKRFE KQKEVIEGYR KNEESLKKCV EDYLARITQE GQRYQALKAH AEEKLQLANE
   781  EIAQVRSKAQ AEALALQASL RKEQMRIQSL EKTVEQKTKE NEELTRICDD LISKMEKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TACC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

testis: 55 nTPM
bone marrow: 53 nTPM
thymus: 48 nTPM
lymph node: 37 nTPM
tonsil: 36 nTPM
spleen: 24 nTPM

Single-cell type

platelets: 255 nCPM
late primary spermatocytes: 224 nCPM
monocyte progenitors: 202 nCPM
megakaryocytes: 198 nCPM
neutrophils: 186 nCPM
oocytes: 180 nCPM

Immune cell

neutrophil: 91 nTPM
basophil: 44 nTPM
T-reg: 41 nTPM
eosinophil: 36 nTPM
total PBMC: 32 nTPM
classical monocyte: 29 nTPM

Brain region

choroid plexus: 3.9 nTPM
thalamus: 2.9 nTPM
medulla oblongata: 2.7 nTPM
pons: 2.6 nTPM
cerebral cortex: 2.4 nTPM
cerebellum: 2.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TACC3.

Disease | ImmuneIEDB

Conditions an epitope on TACC3 was assayed in.

glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: -0.79
DepMap mean gene effect: -0.51
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transforming acidic coiled-coil-containing protein, C-terminal
TACC family
Transforming acidic coiled-coil-containing protein (TACC), C-terminal
TACC3, Aurora-A binding region
TACC3, Aurora-A binding region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TACC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TACC3 as an antibody target. Whether an autoantibody or antibody against TACC3 could matter depends on whether native TACC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TACC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TACC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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