CEBPB
CCAAT/enhancer-binding protein beta
Also known as: C/EBP-beta, CEBPB_HUMAN, CRP2, IL6DBP, LAP, NFIL6, TCF5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P17676
- Gene
- CEBPB
- Ensembl
- ENSG00000172216
- Chromosome
- 20
- Canonical length
- 345 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Canonical amino-acid sequenceUniProt
345 residues, UniProt reviewed canonical sequence.
>P17676|CEBPB
1 MQRLVAWDPA CLPLPPPPPA FKSMEVANFY YEADCLAAAY GGKAAPAAPP AARPGPRPPA
61 GELGSIGDHE RAIDFSPYLE PLGAPQAPAP ATATDTFEAA PPAPAPAPAS SGQHHDFLSD
121 LFSDDYGGKN CKKPAEYGYV SLGRLGAAKG ALHPGCFAPL HPPPPPPPPP AELKAEPGFE
181 PADCKRKEEA GAPGGGAGMA AGFPYALRAY LGYQAVPSGS SGSLSTSSSS SPPGTPSPAD
241 AKAPPTACYA GAAPAPSQVK SKAKKTVDKH SDEYKIRRER NNIAVRKSRD KAKMRNLETQ
301 HKVLELTAEN ERLQKKVEQL SRELSTLRNL FKQLPEPLLA SSGHCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CEBPB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 228 nTPM
Expression across tissuesHPA
Tissue
- liver: 228 nTPM
- skeletal muscle: 206 nTPM
- adipose tissue: 161 nTPM
- lung: 143 nTPM
- adrenal gland: 135 nTPM
- blood vessel: 115 nTPM
Single-cell type
- neutrophils: 2,592 nCPM
- syncytiotrophoblasts: 1,823 nCPM
- extravillous trophoblasts: 983 nCPM
- monocytes: 936 nCPM
- thymic myoid cells: 650 nCPM
- kupffer cells: 577 nCPM
Immune cell
- neutrophil: 17 nTPM
- eosinophil: 13 nTPM
- basophil: 8.6 nTPM
- non-classical monocyte: 7.7 nTPM
- intermediate monocyte: 6.8 nTPM
- classical monocyte: 3.5 nTPM
Brain region
- midbrain: 58 nTPM
- choroid plexus: 58 nTPM
- spinal cord: 57 nTPM
- medulla oblongata: 54 nTPM
- thalamus: 53 nTPM
- hypothalamus: 50 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.02
- gnomAD pLI
- 0.36
- gnomAD missense Z
- 0.9
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- acute-phase response
- brown fat cell differentiation
- cellular response to amino acid stimulus
- cellular response to interleukin-1
- cellular response to lipopolysaccharide
- defense response to bacterium
- embryonic placenta development
- granuloma formation
- hepatocyte proliferation
- immune response
- inflammatory response
- integrated stress response signaling
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- liver regeneration
- mammary gland epithelial cell differentiation
- mammary gland epithelial cell proliferation
- memory
- myeloid cell development
- negative regulation of neuron apoptotic process
- negative regulation of T cell proliferation
- negative regulation of transcription by RNA polymerase II
- neuron differentiation
- ovarian follicle development
- positive regulation of biomineral tissue development
- positive regulation of cold-induced thermogenesis
- positive regulation of DNA-templated transcription
- positive regulation of fat cell differentiation
- positive regulation of inflammatory response
- positive regulation of interleukin-4 production
- positive regulation of osteoblast differentiation
- positive regulation of sodium-dependent phosphate transport
- positive regulation of transcription by RNA polymerase II
- regulation of cell differentiation
- regulation of dendritic cell differentiation
- regulation of DNA-templated transcription
- regulation of interleukin-6 production
- regulation of odontoblast differentiation
- regulation of osteoclast differentiation
- regulation of transcription by RNA polymerase II
- response to endoplasmic reticulum stress
- T-helper 1 cell activation
- transcription by RNA polymerase II
Molecular functions
- chromatin DNA binding
- DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- histone acetyltransferase binding
- histone deacetylase binding
- kinase binding
- nuclear glucocorticoid receptor binding
- protein heterodimerization activity
- protein homodimerization activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II core promoter sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- transcription cis-regulatory region binding
- ubiquitin-like protein ligase binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CEBPB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CEBPB as an antibody target. Whether an autoantibody or antibody against CEBPB could matter depends on whether native CEBPB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CEBPB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CEBPB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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