Seroatlas · Human Serome Atlas

WDHD1

WD repeat and HMG-box DNA-binding protein 1

Also known as: AND-1, CHTF4, CTF4, WDHD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75717
Gene: WDHD1
Ensembl: ENSG00000198554
Chromosome: 14
Canonical length: 1129 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1129 residues, UniProt reviewed canonical sequence.

>O75717|WDHD1
     1  MPATRKPMRY GHTEGHTEVC FDDSGSFIVT CGSDGDVRIW EDLDDDDPKF INVGEKAYSC
    61  ALKSGKLVTA VSNNTIQVHT FPEGVPDGIL TRFTTNANHV VFNGDGTKIA AGSSDFLVKI
   121  VDVMDSSQQK TFRGHDAPVL SLSFDPKDIF LASASCDGSV RVWQISDQTC AISWPLLQKC
   181  NDVINAKSIC RLAWQPKSGK LLAIPVEKSV KLYRRESWSH QFDLSDNFIS QTLNIVTWSP
   241  CGQYLAAGSI NGLIIVWNVE TKDCMERVKH EKGYAICGLA WHPTCGRISY TDAEGNLGLL
   301  ENVCDPSGKT SSSKVSSRVE KDYNDLFDGD DMSNAGDFLN DNAVEIPSFS KGIINDDEDD
   361  EDLMMASGRP RQRSHILEDD ENSVDISMLK TGSSLLKEEE EDGQEGSIHN LPLVTSQRPF
   421  YDGPMPTPRQ KPFQSGSTPL HLTHRFMVWN SIGIIRCYND EQDNAIDVEF HDTSIHHATH
   481  LSNTLNYTIA DLSHEAILLA CESTDELASK LHCLHFSSWD SSKEWIIDLP QNEDIEAICL
   541  GQGWAAAATS ALLLRLFTIG GVQKEVFSLA GPVVSMAGHG EQLFIVYHRG TGFDGDQCLG
   601  VQLLELGKKK KQILHGDPLP LTRKSYLAWI GFSAEGTPCY VDSEGIVRML NRGLGNTWTP
   661  ICNTREHCKG KSDHYWVVGI HENPQQLRCI PCKGSRFPPT LPRPAVAILS FKLPYCQIAT
   721  EKGQMEEQFW RSVIFHNHLD YLAKNGYEYE ESTKNQATKE QQELLMKMLA LSCKLEREFR
   781  CVELADLMTQ NAVNLAIKYA SRSRKLILAQ KLSELAVEKA AELTATQVEE EEEEEDFRKK
   841  LNAGYSNTAT EWSQPRFRNQ VEEDAEDSGE ADDEEKPEIH KPGQNSFSKS TNSSDVSAKS
   901  GAVTFSSQGR VNPFKVSASS KEPAMSMNSA RSTNILDNMG KSSKKSTALS RTTNNEKSPI
   961  IKPLIPKPKP KQASAASYFQ KRNSQTNKTE EVKEENLKNV LSETPAICPP QNTENQRPKT
  1021  GFQMWLEENR SNILSDNPDF SDEADIIKEG MIRFRVLSTE ERKVWANKAK GETASEGTEA
  1081  KKRKRVVDES DETENQEEKA KENLNLSKKQ KPLDFSTNQK LSAFAFKQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDHD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

thymus: 7.5 nTPM
bone marrow: 6.8 nTPM
tonsil: 6.3 nTPM
lymph node: 5.1 nTPM
testis: 4.9 nTPM
rectum: 3.8 nTPM

Single-cell type

erythrocyte progenitors: 179 nCPM
megakaryocyte progenitors: 95 nCPM
differentiating spermatogonia: 88 nCPM
monocyte progenitors: 80 nCPM
early primary spermatocytes: 67 nCPM
megakaryocyte-erythroid progenitors: 57 nCPM

Immune cell

NK-cell: 2 nTPM
basophil: 1.8 nTPM
naive B-cell: 1.8 nTPM
naive CD8 T-cell: 1.8 nTPM
T-reg: 1.6 nTPM
memory CD8 T-cell: 1.3 nTPM

Brain region

basal ganglia: 4.2 nTPM
cerebellum: 4 nTPM
cerebral cortex: 3.9 nTPM
white matter: 3.8 nTPM
hippocampal formation: 3.5 nTPM
amygdala: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: -1.33
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
High mobility group box domain
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
High mobility group box domain superfamily
WDHD1/CFT4, second beta-propeller
WDHD1/CFT4, helical bundle
WD repeat and HMG-box DNA-binding protein 1, HMG-box
WDHD1, first WD40 domain
Minichromosome loss protein, Mcl1, middle region
DNA polymerase alpha-binding protein Ctf4, C-terminal domain
WDHD1 HMG box
WDHD1 first WD40 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDHD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDHD1 as an antibody target. Whether an autoantibody or antibody against WDHD1 could matter depends on whether native WDHD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDHD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDHD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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