Seroatlas · Human Serome Atlas

STK25

Serine/threonine-protein kinase 25

Also known as: SOK1, STK25_HUMAN, YSK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00506
Gene
STK25
Ensembl
ENSG00000115694
Chromosome
2
Canonical length
426 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>O00506|STK25
     1  MAHLRGFANQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN HTKEVVAIKI IDLEEAEDEI
    61  EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG GSALDLLKPG PLEETYIATI
   121  LREILKGLDY LHSERKIHRD IKAANVLLSE QGDVKLADFG VAGQLTDTQI KRNTFVGTPF
   181  WMAPEVIKQS AYDFKADIWS LGITAIELAK GEPPNSDLHP MRVLFLIPKN SPPTLEGQHS
   241  KPFKEFVEAC LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW KSEGHGEESS
   301  SEDSDIDGEA EDGEQGPIWT FPPTIRPSPH SKLHKGTALH SSQKPAEPVK RQPRSQCLST
   361  LVRPVFGELK EKHKQSGGSV GALEELENAF SLAEESCPGI SDKLMVHLVE RVQRFSHNRN
   421  HLTSTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
460 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 460 nTPM
  • tongue: 199 nTPM
  • cerebral cortex: 92 nTPM
  • basal ganglia: 84 nTPM
  • cerebellum: 78 nTPM
  • amygdala: 77 nTPM

Single-cell type

  • cytotrophoblasts: 105 nCPM
  • extravillous trophoblasts: 104 nCPM
  • early primary spermatocytes: 97 nCPM
  • esophageal suprabasal cells: 94 nCPM
  • esophageal apical cells: 93 nCPM
  • esophageal basal cells: 82 nCPM

Immune cell

  • NK-cell: 25 nTPM
  • T-reg: 23 nTPM
  • non-classical monocyte: 20 nTPM
  • memory CD8 T-cell: 19 nTPM
  • gdT-cell: 17 nTPM
  • basophil: 17 nTPM

Brain region

  • cerebral cortex: 132 nTPM
  • amygdala: 121 nTPM
  • hypothalamus: 120 nTPM
  • basal ganglia: 117 nTPM
  • hippocampal formation: 116 nTPM
  • pons: 114 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.05
gnomAD missense Z
2.23
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STK25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK25 as an antibody target. Whether an autoantibody or antibody against STK25 could matter depends on whether native STK25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STK25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STK25. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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