Seroatlas · Human Serome Atlas

ZFPL1

Zinc finger protein-like 1

Also known as: D11S750, MCG4, ZFPL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95159
Gene
ZFPL1
Ensembl
ENSG00000162300
Chromosome
11
Canonical length
310 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>O95159|ZFPL1
     1  MGLCKCPKRK VTNLFCFEHR VNVCEHCLVA NHAKCIVQSY LQWLQDSDYN PNCRLCNIPL
    61  ASRETTRLVC YDLFHWACLN ERAAQLPRNT APAGYQCPSC NGPIFPPTNL AGPVASALRE
   121  KLATVNWARA GLGLPLIDEV VSPEPEPLNT SDFSDWSSFN ASSTPGPEEV DSASAAPAFY
   181  SQAPRPPASP GRPEQHTVIH MGNPEPLTHA PRKVYDTRDD DRTPGLHGDC DDDKYRRRPA
   241  LGWLARLLRS RAGSRKRPLT LLQRAGLLLL LGLLGFLALL ALMSRLGRAA ADSDPNLDPL
   301  MNPHIRVGPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 35 nTPM
  • blood vessel: 34 nTPM
  • skeletal muscle: 34 nTPM
  • choroid plexus: 32 nTPM
  • skin: 31 nTPM
  • adrenal gland: 29 nTPM

Single-cell type

  • epididymal principal cells: 102 nCPM
  • syncytiotrophoblasts: 82 nCPM
  • late spermatids: 81 nCPM
  • esophageal apical cells: 66 nCPM
  • extravillous trophoblasts: 60 nCPM
  • cytotrophoblasts: 57 nCPM

Immune cell

  • basophil: 77 nTPM
  • eosinophil: 42 nTPM
  • neutrophil: 27 nTPM
  • T-reg: 26 nTPM
  • NK-cell: 24 nTPM
  • intermediate monocyte: 21 nTPM

Brain region

  • white matter: 27 nTPM
  • basal ganglia: 26 nTPM
  • thalamus: 26 nTPM
  • medulla oblongata: 26 nTPM
  • cerebellum: 25 nTPM
  • cerebral cortex: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0.01
gnomAD missense Z
0.36
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Zinc finger, RING/FYVE/PHD-type
  • Zinc finger protein-like 1
  • ZFPL1-like, U-box domain
  • ZFPL1-like, B-box zinc-binding domain
  • ZFPL1-like, B-box zinc-binding domain
  • ZFPL1-like, U-box domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFPL1 as an antibody target. Whether an autoantibody or antibody against ZFPL1 could matter depends on whether native ZFPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFPL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZFPL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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