Seroatlas · Human Serome Atlas

RHPN1

Rhophilin-1

Also known as: KIAA1929, ODF5, RHPN, RHPN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCX5
Gene: RHPN1
Ensembl: ENSG00000158106
Chromosome: 8
Canonical length: 670 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in negative regulation of stress fiber assembly. Predicted to act upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and renal albumin absorption. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>Q8TCX5|RHPN1
     1  MILEERPDGA GAGEESPRLQ GCDSLTQIQC GQLQSRRAQI HQQIDKELQM RTGAENLYRA
    61  TSNNRVRETV ALELSYVNSN LQLLKEELEE LSGGVDPGRH GSEAVTVPMI PLGLKETKEL
   121  DWSTPLKELI SVHFGEDGAS YEAEIRELEA LRQAMRTPSR NESGLELLTA YYNQLCFLDA
   181  RFLTPARSLG LFFHWYDSLT GVPAQQRALA FEKGSVLFNI GALHTQIGAR QDRSCTEGAR
   241  RAMEAFQRAA GAFSLLRENF SHAPSPDMSA ASLCALEQLM MAQAQECVFE GLSPPASMAP
   301  QDCLAQLRLA QEAAQVAAEY RLVHRTMAQP PVHDYVPVSW TALVHVKAEY FRSLAHYHVA
   361  MALCDGSPAT EGELPTHEQV FLQPPTSSKP RGPVLPQELE ERRQLGKAHL KRAILGQEEA
   421  LRLHALCRVL REVDLLRAVI SQTLQRSLAK YAELDREDDF CEAAEAPDIQ PKTHQKPEAR
   481  MPRLSQGKGP DIFHRLGPLS VFSAKNRWRL VGPVHLTRGE GGFGLTLRGD SPVLIAAVIP
   541  GSQAAAAGLK EGDYIVSVNG QPCRWWRHAE VVTELKAAGE AGASLQVVSL LPSSRLPSLG
   601  DRRPVLLGPR GLLRSQREHG CKTPASTWAS PRPLLNWSRK AQQGKTGGCP QPCAPVKPAP
   661  PSSLKHPGWP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHPN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 19 nTPM
pituitary gland: 19 nTPM
cerebral cortex: 16 nTPM
hippocampal formation: 16 nTPM
kidney: 15 nTPM
amygdala: 14 nTPM

Single-cell type

astrocytes: 72 nCPM
respiratory ciliated cells: 68 nCPM
fallopian tube ciliated cells: 50 nCPM
ependymal cells: 47 nCPM
proximal tubule cells: 40 nCPM
epididymal efferent duct ciliated cells: 40 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 30 nTPM
amygdala: 26 nTPM
cerebral cortex: 24 nTPM
thalamus: 23 nTPM
midbrain: 22 nTPM
hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHPN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHPN1 as an antibody target. Whether an autoantibody or antibody against RHPN1 could matter depends on whether native RHPN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHPN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHPN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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