Seroatlas · Human Serome Atlas

GRIP1

Glutamate receptor-interacting protein 1

Also known as: GRIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y3R0
Gene
GRIP1
Ensembl
ENSG00000155974
Chromosome
12
Canonical length
1128 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters
Quaternary structure
Homomultimer

OverviewNCBI Gene

This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

1128 residues, UniProt reviewed canonical sequence.

>Q9Y3R0|GRIP1
     1  MIAVSFKCRC QILRRLTKDE SPYTKSASQT KPPDGALAVR RQSIPEEFKG STVVELMKKE
    61  GTTLGLTVSG GIDKDGKPRV SNLRQGGIAA RSDQLDVGDY IKAVNGINLA KFRHDEIISL
   121  LKNVGERVVL EVEYELPPVS VQGSSVIFRT VEVTLHKEGN TFGFVIRGGA HDDRNKSRPV
   181  VITCVRPGGP ADREGTIKPG DRLLSVDGIR LLGTTHAEAM SILKQCGQEA ALLIEYDVSV
   241  MDSVATASGP LLVEVAKTPG ASLGVALTTS MCCNKQVIVI DKIKSASIAD RCGALHVGDH
   301  ILSIDGTSME YCTLAEATQF LANTTDQVKL EILPHHQTRL ALKGPDHVKI QRSDRQLTWD
   361  SWASNHSSLH TNHHYNTYHP DHCRVPALTF PKAPPPNSPP ALVSSSFSPT SMSAYSLSSL
   421  NMGTLPRSLY STSPRGTMMR RRLKKKDFKS SLSLASSTVG LAGQVVHTET TEVVLTADPV
   481  TGFGIQLQGS VFATETLSSP PLISYIEADS PAERCGVLQI GDRVMAINGI PTEDSTFEEA
   541  SQLLRDSSIT SKVTLEIEFD VAESVIPSSG TFHVKLPKKH NVELGITISS PSSRKPGDPL
   601  VISDIKKGSV AHRTGTLELG DKLLAIDNIR LDNCSMEDAV QILQQCEDLV KLKIRKDEDN
   661  SDEQESSGAI IYTVELKRYG GPLGITISGT EEPFDPIIIS SLTKGGLAER TGAIHIGDRI
   721  LAINSSSLKG KPLSEAIHLL QMAGETVTLK IKKQTDAQSA SSPKKFPISS HLSDLGDVEE
   781  DSSPAQKPGK LSDMYPSTVP SVDSAVDSWD GSAIDTSYGT QGTSFQASGY NFNTYDWRSP
   841  KQRGSLSPVT KPRSQTYPDV GLSYEDWDRS TASGFAGAAD SAETEQEENF WSQALEDLET
   901  CGQSGILREL EEKADRRVSL RNMTLLATIM SGSTMSLNHE APTPRSQLGR QASFQERSSS
   961  RPHYSQTTRS NTLPSDVGRK SVTLRKMKQE IKEIMSPTPV ELHKVTLYKD SDMEDFGFSV
  1021  ADGLLEKGVY VKNIRPAGPG DLGGLKPYDR LLQVNHVRTR DFDCCLVVPL IAESGNKLDL
  1081  VISRNPLASQ KSIDQQSLPG DWSEQNSAFF QQPSHGGNLE TREPTNTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 15 nTPM
  • skin: 9.2 nTPM
  • seminal vesicle: 8.7 nTPM
  • placenta: 7.7 nTPM
  • esophagus: 6.8 nTPM
  • salivary gland: 5.6 nTPM

Single-cell type

  • renal collecting duct principal cells: 3,017 nCPM
  • retinal amacrine cells: 1,980 nCPM
  • renal connecting tubule cells: 1,420 nCPM
  • renal collecting duct intercalated cells: 1,375 nCPM
  • brain inhibitory neurons: 1,319 nCPM
  • retinal horizontal cells: 1,038 nCPM

Immune cell

  • myeloid DC: 4.8 nTPM
  • NK-cell: 1 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 60 nTPM
  • hypothalamus: 56 nTPM
  • basal ganglia: 47 nTPM
  • midbrain: 46 nTPM
  • white matter: 37 nTPM
  • amygdala: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GRIP1.

Disease | AllUniProt

Conditions GRIP1 is implicated in, by any mechanism.

Disease | GeneticClinVar

31 pathogenic / likely-pathogenic of 847 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.51
gnomAD missense Z
1.58
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRIP1 as an antibody target. Whether an autoantibody or antibody against GRIP1 could matter depends on whether native GRIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRIP1 is annotated at the cell surface, where native GRIP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GRIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GRIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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