Seroatlas · Human Serome Atlas

PPFIA4

Liprin-alpha-4

Also known as: LIPA4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75335
Gene: PPFIA4
Ensembl: ENSG00000143847
Chromosome: 1
Canonical length: 1185 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1185 residues, UniProt reviewed canonical sequence.

>O75335|PPFIA4
     1  MCEVMPTINE GDRLGPPHGA DADANFEQLM VNMLDEREKL LESLRESQET LAATQSRLQD
    61  AIHERDQLQR HLNSALPQEF ATLTRELSMC REQLLEREEE ISELKAERNN TRLLLEHLEC
   121  LVSRHERSLR MTVVKRQAQS PSGVSSEVEV LKALKSLFEH HKALDEKVRE RLRAALERVT
   181  TLEEQLAGAH QQVSALQQGA GVRDGAAEEE GTVELGPKRL WKEDTGRVEE LQELLEKQNF
   241  ELSQARERLV TLTTTVTELE EDLGTARRDL IKSEELSSKH QRDLREALAQ KEDMEERITT
   301  LEKRYLAAQR EATSIHDLND KLENELANKE SLHRQCEEKA RHLQELLEVA EQKLQQTMRK
   361  AETLPEVEAE LAQRIAALTK AEERHGNIEE HLRQLEGQLE EKNQELARTA VQVRQREKMN
   421  EDHNKRLSDT VDRLLSESNE RLQLHLKERM AALEEKNTLI QELESSQRQI EEQHHHKGRL
   481  SEEIEKLRQE VDQLKGRGGP FVDGVHSRSH MGSAADVRFS LGTTTHAPPG VHRRYSALRE
   541  ESAKLALPLT VTLRSPTWMR MSQGVCCNLE YHSSGTLCGS SGPLPVPEMI QEEKESTELR
   601  AEEIETRVTS GSMEALNLKQ LRKRGSIPTS LTALSLASAS PPLSGRSTPK LTSRSAAQDL
   661  DRMGVMTLPS DLRKHRRKLL SPVSREENRE DKATIKCETS PPSSPRTLRL EKLGHPALSQ
   721  EEGKSALEDQ GSNPSSSNSS QDSLHKGAKR KGIKSSIGRL FGKKEKGRLI QLSRDGATGH
   781  VLLTDSEFSM QEPMVPAKLG TQAEKDRRLK KKHQLLEDAR RKGMPFAQWD GPTVVSWLEL
   841  WVGMPAWYVA ACRANVKSGA IMSALSDTEI QREIGISNAL HRLKLRLAIQ EMVSLTSPSA
   901  PPTSRTSSGN VWVTHEEMET LETSTKTDSE EGSWAQTLAY GDMNHEWIGN EWLPSLGLPQ
   961  YRSYFMECLV DARMLDHLTK KDLRVHLKMV DSFHRTSLQY GIMCLKRLNY DRKELEKRRE
  1021  ESQHEIKDVL VWTNDQVVHW VQSIGLRDYA GNLHESGVHG ALLALDENFD HNTLALILQI
  1081  PTQNTQARQV MEREFNNLLA LGTDRKLDDG DDKVFRRAPS WRKRFRPREH HGRGGMLSAS
  1141  AETLPAGFRV STLGTLQPPP APPKKIMPEA HSHYLYGHML SAFRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPFIA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 97 nTPM
cerebral cortex: 21 nTPM
skeletal muscle: 17 nTPM
heart muscle: 15 nTPM
amygdala: 12 nTPM
basal ganglia: 11 nTPM

Single-cell type

podocytes: 170 nCPM
brain excitatory neurons: 91 nCPM
retinal amacrine cells: 50 nCPM
retinal ganglion cells: 50 nCPM
brain inhibitory neurons: 48 nCPM
myonuclei: 44 nCPM

Immune cell

eosinophil: 0.2 nTPM
myeloid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 191 nTPM
cerebral cortex: 149 nTPM
amygdala: 88 nTPM
white matter: 78 nTPM
hippocampal formation: 77 nTPM
basal ganglia: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 1.97
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

synapse organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPFIA4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPFIA4 as an antibody target. Whether an autoantibody or antibody against PPFIA4 could matter depends on whether native PPFIA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPFIA4 is annotated at the cell surface, where native PPFIA4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PPFIA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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