GRK6

Protein identityUniProt · HPA

UniProt accession

P43250

Gene

GRK6

Ensembl

ENSG00000198055

Chromosome

5

Canonical length

576 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

576 residues, UniProt reviewed canonical sequence.

>P43250|GRK6
     1  MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ
    61  PIGRLLFREF CATRPELSRC VAFLDGVAEY EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE
   121  VPRQLVTNCT QRLEQGPCKD LFQELTRLTH EYLSVAPFAD YLDSIYFNRF LQWKWLERQP
   181  VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK
   241  VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE
   301  DLHRERIVYR DLKPENILLD DHGHIRISDL GLAVHVPEGQ TIKGRVGTVG YMAPEVVKNE
   361  RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVPEEYSE RFSPQARSLC
   421  SQLLCKDPAE RLGCRGGSAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI
   481  EQFSTVKGVE LEPTDQDFYQ KFATGSVPIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK
   541  GQPPAPPKKG LLQRLFSRQD CCGNCSDSEE ELPTRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

127 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.57

gnomAD pLI

0

gnomAD missense Z

2.81

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled receptor signaling pathway
• regulation of G protein-coupled receptor signaling pathway
• regulation of signal transduction
• Wnt signaling pathway

Molecular functions

• ATP binding
• beta-adrenergic receptor kinase activity
• G protein-coupled receptor kinase activity

Cellular components

• cytoplasm
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• GPCR kinase
• Protein kinase domain
• AGC-kinase, C-terminal
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• RGS domain
• Protein kinase, ATP binding site
• RGS domain superfamily
• RGS, subdomain 2
• Protein kinase domain
• Regulator of G protein signaling domain

KeywordsUniProt

• ATP-binding
• Kinase
• Lipoprotein
• Membrane
• Nucleotide-binding
• Palmitate
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase
• Wnt signaling pathway

InteractionsUniProt · HPA

Protein binding partners of GRK6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GIT1
• GRK4
• HSP90AB1