Seroatlas · Human Serome Atlas

CAMK1

Calcium/calmodulin-dependent protein kinase type 1

Also known as: CaMKI, CaMKI-alpha, KCC1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14012
Gene
CAMK1
Ensembl
ENSG00000134072
Chromosome
3
Canonical length
370 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q14012|CAMK1
     1  MLGAVEGPRW KQAEDIRDIY DFRDVLGTGA FSEVILAEDK RTQKLVAIKC IAKEALEGKE
    61  GSMENEIAVL HKIKHPNIVA LDDIYESGGH LYLIMQLVSG GELFDRIVEK GFYTERDASR
   121  LIFQVLDAVK YLHDLGIVHR DLKPENLLYY SLDEDSKIMI SDFGLSKMED PGSVLSTACG
   181  TPGYVAPEVL AQKPYSKAVD CWSIGVIAYI LLCGYPPFYD ENDAKLFEQI LKAEYEFDSP
   241  YWDDISDSAK DFIRHLMEKD PEKRFTCEQA LQHPWIAGDT ALDKNIHQSV SEQIKKNFAK
   301  SKWKQAFNAT AVVRHMRKLQ LGTSQEGQGQ TASHGELLTP VAGGPAAGCC CRDCCVEPGT
   361  ELSPTLPHQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 100 nTPM
  • basal ganglia: 68 nTPM
  • amygdala: 66 nTPM
  • cerebral cortex: 64 nTPM
  • hippocampal formation: 59 nTPM
  • adipose tissue: 51 nTPM

Single-cell type

  • megakaryocytes: 334 nCPM
  • adrenal cortex cells: 106 nCPM
  • sertoli cells: 77 nCPM
  • megakaryocyte progenitors: 66 nCPM
  • smooth muscle cells: 58 nCPM
  • monocytes: 57 nCPM

Immune cell

  • eosinophil: 281 nTPM
  • non-classical monocyte: 43 nTPM
  • intermediate monocyte: 42 nTPM
  • classical monocyte: 21 nTPM
  • basophil: 18 nTPM
  • myeloid DC: 14 nTPM

Brain region

  • hippocampal formation: 76 nTPM
  • cerebral cortex: 76 nTPM
  • amygdala: 52 nTPM
  • basal ganglia: 50 nTPM
  • hypothalamus: 46 nTPM
  • white matter: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAMK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAMK1 as an antibody target. Whether an autoantibody or antibody against CAMK1 could matter depends on whether native CAMK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAMK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAMK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAMK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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