C8orf33
UPF0488 protein C8orf33
Also known as: CH033_HUMAN, FLJ20989
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H7E9
- Gene
- C8orf33
- Ensembl
- ENSG00000182307
- Chromosome
- 8
- Canonical length
- 229 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Plasma membrane
OverviewNCBI Gene
No narrative summary is available for C8orf33 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
229 residues, UniProt reviewed canonical sequence.
>Q9H7E9|C8orf33
1 MAALGHLAGE AAAAPGPGTP CASRGARLPG PVSSARNPST VCLCPEQPTC SNADSRAHPL
61 GDEGGTASKK QKNKKKTRNR ASVANGGEKA SEKLAPEEVP LSAEAQAQQL AQELAWCVEQ
121 LELGLKRQKP TPKQKEQAIG AIRTLRSKRT PLPRKRQLMH SLFGDYRAQM EAEWREALRA
181 LRAAAYSAQV QPVDGATRKK SQRVCRPRSI WRAKATLDMP DEEFRFNFFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C8orf33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 51 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 51 nTPM
- ovary: 43 nTPM
- parathyroid gland: 32 nTPM
- rectum: 31 nTPM
- thyroid gland: 31 nTPM
- epididymis: 26 nTPM
Single-cell type
- colonocytes: 92 nCPM
- megakaryocytes: 74 nCPM
- hepatocytes: 69 nCPM
- erythrocyte progenitors: 64 nCPM
- ovarian stromal cells: 59 nCPM
- esophageal suprabasal cells: 59 nCPM
Immune cell
- NK-cell: 28 nTPM
- naive CD4 T-cell: 21 nTPM
- myeloid DC: 20 nTPM
- MAIT T-cell: 19 nTPM
- plasmacytoid DC: 18 nTPM
- memory CD8 T-cell: 18 nTPM
Brain region
- midbrain: 26 nTPM
- cerebral cortex: 25 nTPM
- medulla oblongata: 24 nTPM
- cerebellum: 24 nTPM
- hypothalamus: 23 nTPM
- pons: 23 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.45
- DepMap mean gene effect
- -0.26
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4615
- Domain of unknown function (DUF4615)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of C8orf33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C8orf33 as an antibody target. Whether an autoantibody or antibody against C8orf33 could matter depends on whether native C8orf33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C8orf33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C8orf33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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