Seroatlas · Human Serome Atlas

HMOX2

Heme oxygenase 2

Also known as: HMOX2_HUMAN, HO-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30519
Gene
HMOX2
Ensembl
ENSG00000103415
Chromosome
16
Canonical length
316 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>P30519|HMOX2
     1  MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN TQFVKDFLKG
    61  NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN
   121  WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST
   181  GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA
   241  GSTLARETLE DGFPVHDGKG DMRKCPFYAA EQDKGALEGS SCPFRTAMAV LRKPSLQFIL
   301  AAGVALAAGL LAWYYM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMOX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
147 nTPM

Expression across tissuesHPA

Tissue

  • testis: 147 nTPM
  • heart muscle: 138 nTPM
  • liver: 103 nTPM
  • stomach: 98 nTPM
  • basal ganglia: 94 nTPM
  • cerebral cortex: 88 nTPM

Single-cell type

  • late spermatids: 2,469 nCPM
  • early spermatids: 470 nCPM
  • esophageal apical cells: 273 nCPM
  • late primary spermatocytes: 201 nCPM
  • early primary spermatocytes: 156 nCPM
  • parietal cells: 110 nCPM

Immune cell

  • eosinophil: 253 nTPM
  • memory CD8 T-cell: 169 nTPM
  • gdT-cell: 167 nTPM
  • T-reg: 156 nTPM
  • memory CD4 T-cell: 154 nTPM
  • naive CD8 T-cell: 152 nTPM

Brain region

  • cerebellum: 77 nTPM
  • pons: 77 nTPM
  • medulla oblongata: 72 nTPM
  • cerebral cortex: 72 nTPM
  • thalamus: 72 nTPM
  • white matter: 68 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HMOX2.

Disease | ImmuneIEDB

Conditions an epitope on HMOX2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMOX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMOX2 as an antibody target. Whether an autoantibody or antibody against HMOX2 could matter depends on whether native HMOX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMOX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMOX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HMOX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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