Seroatlas · Human Serome Atlas

FYB2

FYN-binding protein 2

Also known as: ARAP, C1orf168, FLJ43208, FYB2_HUMAN, RP4-758N20.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VWT5
Gene
FYB2
Ensembl
ENSG00000187889
Chromosome
1
Canonical length
728 aa
Protein class
Predicted intracellular proteins
Subcellular location
Perinuclear theca,Mid piece,Principal piece

OverviewNCBI Gene

Involved in T cell receptor signaling pathway and cell adhesion mediated by integrin. Located in immunological synapse and membrane raft. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

728 residues, UniProt reviewed canonical sequence.

>Q5VWT5|FYB2
     1  MEGEGVRNFK ELRAKFQNLD APPLPGPIKF PAGVSPKGDI GGTQSTQILA NGKPLSSNHK
    61  QRTPYCSSSE SQPLQPQKIK LAQKSEIPKC SNSPGPLGKS TVCSATSSQK ASLLLEVTQS
   121  NVEIITKEKV MVANSFRNKL WNWEKVSSQK SEMSSALLLA NYGSKAIHLE GQKGMGLTPE
   181  EPRKKLETKG AQTLPSQKHV VAPKILHNVS EDPSFVISQH IRKSWENPPP ERSPASSPCQ
   241  PIYECELASQ APEKQPDVRH HHLPKTKPLP SIDSLGPPPP KPSRPPIVNL QAFQRQPAAV
   301  PKTQGEVTVE EGSLSPERLF NAEFEEPHNY EATISYLRHS GNSINLCTAK EIADPTYEVG
   361  IEELQKPGKN FPYPEPSAKH EDKKMKEKQP CELKPKNTEK EPYSNHVFKV DACEGTPEKI
   421  QMTNVHTGRR NMLAGKQEAM IDIIQTNPCP EGPKLARHSQ GHCGHLEVLE STKETPDLGV
   481  SKTSSISEEI YDDVEYSRKE VPKLNYSSSL ASSSEENREL YEDVYKTKNN YPKIDLDGKE
   541  ALKRLQQFFK KEKDRFKIKK TKSKENLSAF SILLPDLELK SQEVIIYDDV DLSEKESKDE
   601  DKLKMWKPKF LTPKEKKEKN GAEESESFSP RNFFKTKKQN LEKNRMKREE KLFRERFKYD
   661  KEIIVINTAV ACSNNSRNGI FDLPISPGEE LEVIDTTEQN LVICRNSKGK YGYVLIEHLD
   721  FKHQSWSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FYB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • liver: 16 nTPM
  • fallopian tube: 13 nTPM
  • choroid plexus: 11 nTPM
  • parathyroid gland: 5.9 nTPM
  • cervix: 3.4 nTPM
  • kidney: 3.3 nTPM

Single-cell type

  • choroid plexus epithelial cells: 943 nCPM
  • renal collecting duct intercalated cells: 795 nCPM
  • retinal pigment epithelial cells: 567 nCPM
  • respiratory ionocytes: 561 nCPM
  • renal collecting duct principal cells: 420 nCPM
  • epididymal clear cells: 382 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 31 nTPM
  • hippocampal formation: 2.4 nTPM
  • cerebellum: 1.8 nTPM
  • basal ganglia: 0.7 nTPM
  • white matter: 0.7 nTPM
  • hypothalamus: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FYB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FYB2 as an antibody target. Whether an autoantibody or antibody against FYB2 could matter depends on whether native FYB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FYB2 is annotated at the cell surface, where native FYB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FYB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FYB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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