Seroatlas · Human Serome Atlas

CWC22

Pre-mRNA-splicing factor CWC22 homolog

Also known as: CWC22_HUMAN, EIF4GL, fSAPb, KIAA1604, NCM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCG8
Gene: CWC22
Ensembl: ENSG00000163510
Chromosome: 2
Canonical length: 908 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

908 residues, UniProt reviewed canonical sequence.

>Q9HCG8|CWC22
     1  MKSSVAQIKP SSGHDRRENL NSYQRNSSPE DRYEEQERSP RDRDYFDYSR SDYEHSRRGR
    61  SYDSSMESRN RDREKRRERE RDTDRKRSRK SPSPGRRNPE TSVTQSSSAQ DEPATKKKKD
   121  ELDPLLTRTG GAYIPPAKLR MMQEQITDKN SLAYQRMSWE ALKKSINGLI NKVNISNISI
   181  IIQELLQENI VRGRGLLSRS VLQAQSASPI FTHVYAALVA IINSKFPQIG ELILKRLILN
   241  FRKGYRRNDK QLCLTASKFV AHLINQNVAH EVLCLEMLTL LLERPTDDSV EVAIGFLKEC
   301  GLKLTQVSPR GINAIFERLR NILHESEIDK RVQYMIEVMF AVRKDGFKDH PIILEGLDLV
   361  EEDDQFTHML PLEDDYNPED VLNVFKMDPN FMENEEKYKA IKKEILDEGD TDSNTDQDAG
   421  SSEEDEEEEE EEGEEDEEGQ KVTIHDKTEI NLVSFRRTIY LAIQSSLDFE ECAHKLLKME
   481  FPESQTKELC NMILDCCAQQ RTYEKFFGLL AGRFCMLKKE YMESFEGIFK EQYDTIHRLE
   541  TNKLRNVAKM FAHLLYTDSL PWSVLECIKL SEETTTSSSR IFVKIFFQEL CEYMGLPKLN
   601  ARLKDETLQP FFEGLLPRDN PRNTRFAINF FTSIGLGGLT DELREHLKNT PKVIVAQKPD
   661  VEQNKSSPSS SSSASSSSES DSSDSDSDSS DSSSESSSEE SDSSSISSHS SASANDVRKK
   721  GHGKTRSKEV DKLIRNQQTN DRKQKERRQE HGHQETRTER ERRSEKHRDQ NSSGSNWRDP
   781  ITKYTSDKDV PSERNNYSRV ANDRDQEMHI DLENKHGDPK KKRGERRNSF SENEKHTHRI
   841  KDSENFRRKD RSKSKEMNRK HSGSRSDEDR YQNGAERRWE KSSRYSEQSR ESKKNQDRRR
   901  EKSPAKQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CWC22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

thymus: 20 nTPM
lymph node: 17 nTPM
tonsil: 17 nTPM
endometrium: 16 nTPM
liver: 16 nTPM
ovary: 16 nTPM

Single-cell type

neutrophils: 94 nCPM
neutrophil progenitors: 84 nCPM
pituicytes/fscs: 68 nCPM
lactotrophs: 62 nCPM
somatotrophs: 61 nCPM
esophageal apical cells: 55 nCPM

Immune cell

basophil: 50 nTPM
eosinophil: 32 nTPM
neutrophil: 22 nTPM
naive CD4 T-cell: 21 nTPM
memory CD8 T-cell: 20 nTPM
memory B-cell: 18 nTPM

Brain region

cerebellum: 29 nTPM
white matter: 19 nTPM
cerebral cortex: 18 nTPM
basal ganglia: 17 nTPM
amygdala: 16 nTPM
spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: -1.55
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CWC22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CWC22 as an antibody target. Whether an autoantibody or antibody against CWC22 could matter depends on whether native CWC22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CWC22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CWC22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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