Seroatlas · Human Serome Atlas

NRDE2

Nuclear exosome regulator NRDE2

Also known as: C14orf102, FLJ14051, NRDE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H7Z3
Gene
NRDE2
Ensembl
ENSG00000119720
Chromosome
14
Canonical length
1164 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

Involved in several processes, including RNA splicing; mRNA stabilization; and positive regulation of RNA export from nucleus. Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1164 residues, UniProt reviewed canonical sequence.

>Q9H7Z3|NRDE2
     1  MALFPAFAGL SEAPDGGSSR KELDWLSNPS FCVGSITSLS QQTEAAPAHV SEGLPLTRSH
    61  LKSESSDESD TNKKLKQTSR KKKKEKKKKR KHQHHKKTKR KHGPSSSSRS ETDTDSEKDK
   121  PSRGVGGSKK ESEEPNQGNN AAADTGHRFV WLEDIQAVTG ETFRTDKKPD PANWEYKSLY
   181  RGDIARYKRK GDSCLGINPK KQCISWEGTS TEKKHSRKQV ERYFTKKSVG LMNIDGVAIS
   241  SKTEPPSSEP ISFIPVKDLE DAAPVTTWLN PLGIYDQSTT HWLQGQGPPE QESKQPDAQP
   301  DSESAALKAK VEEFNRRVRE NPRDTQLWMA FVAFQDEVMK SPGLYAIEEG EQEKRKRSLK
   361  LILEKKLAIL ERAIESNQSS VDLKLAKLKL CTEFWEPSTL VKEWQKLIFL HPNNTALWQK
   421  YLLFCQSQFS TFSISKIHSL YGKCLSTLSA VKDGSILSHP ALPGTEEAMF ALFLQQCHFL
   481  RQAGHSEKAI SLFQAMVDFT FFKPDSVKDL PTKGQVEFFE PFWDSGEPRA GEKGARGWKA
   541  WMHQQERGGW VVINPDEDDD EPEEDDQEIK DKTLPRWQIW LAAERSRDQR HWRPWRPDKT
   601  KKQTEEDCED PERQVLFDDI GQSLIRLSSH DLQFQLVEAF LQFLGVPSGF TPPASCLYLA
   661  MDENSIFDNG LYDEKPLTFF NPLFSGASCV GRMDRLGYPR WTRGQNREGE EFIRNVFHLV
   721  MPLFSGKEKS QLCFSWLQYE IAKVIWCLHT KNKKRLKSQG KNCKKLAKNL LKEPENCNNF
   781  CLWKQYAHLE WLLGNTEDAR KVFDTALGMA GSRELKDSDL CELSLLYAEL EVELSPEVRR
   841  AATARAVHIL TKLTESSPYG PYTGQVLAVH ILKARKAYEH ALQDCLGDSC VSNPAPTDSC
   901  SRLISLAKCF MLFQYLTIGI DAAVQIYEQV FAKLNSSVFP EGSGEGDSAS SQSWTSVLEA
   961  ITLMHTSLLR FHMKVSVYPL APLREALSQA LKLYPGNQVL WRSYVQIQNK SHSASKTRRF
  1021  FDTITRSAKP LEPWLFAIEA EKLRKRLVET VQRLDGREIH ATIPETGLMH RIQALFENAM
  1081  RSDSGSQCPL LWRMYLNFLV SLGNKERSKG VFYKALQNCP WAKVLYLDAV EYFPDEMQEI
  1141  LDLMTEKELR VRLPLEELEL LLED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRDE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
3.8 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 3.8 nTPM
  • bone marrow: 3.2 nTPM
  • retina: 2.9 nTPM
  • duodenum: 2.4 nTPM
  • skin: 1.9 nTPM
  • liver: 1.7 nTPM

Single-cell type

  • corticotrophs: 85 nCPM
  • thyrotrophs: 77 nCPM
  • pituicytes/fscs: 73 nCPM
  • myonuclei: 71 nCPM
  • lactotrophs: 70 nCPM
  • rod photoreceptor cells: 67 nCPM

Immune cell

  • basophil: 1.5 nTPM
  • neutrophil: 1.3 nTPM
  • plasmacytoid DC: 1.1 nTPM
  • eosinophil: 1 nTPM
  • naive B-cell: 0.9 nTPM
  • classical monocyte: 0.8 nTPM

Brain region

  • cerebellum: 19 nTPM
  • white matter: 11 nTPM
  • basal ganglia: 9.3 nTPM
  • cerebral cortex: 9.2 nTPM
  • thalamus: 9.1 nTPM
  • hypothalamus: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
0.17
DepMap mean gene effect
-1.17
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NRDE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRDE2 as an antibody target. Whether an autoantibody or antibody against NRDE2 could matter depends on whether native NRDE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRDE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRDE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NRDE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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