Seroatlas · Human Serome Atlas

RNF139

E3 ubiquitin-protein ligase RNF139

Also known as: HRCA1, RCA1, RN139_HUMAN, TRC8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WU17
Gene
RNF139
Ensembl
ENSG00000170881
Chromosome
8
Canonical length
664 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

664 residues, UniProt reviewed canonical sequence.

>Q8WU17|RNF139
     1  MAAVGPPQQQ VRMAHQQVWA ALEVALRVPC LYIIDAIFNS YPDSSQSRFC IVLQIFLRLF
    61  GVFASSIVLI LSQRSLFKFY TYSSAFLLAA TSVLVNYYAS LHIDFYGAYN TSAFGIELLP
   121  RKGPSLWMAL IVLQLTFGIG YVTLLQIHSI YSQLIILDLL VPVIGLITEL PLHIRETLLF
   181  TSSLILTLNT VFVLAVKLKW FYYSTRYVYL LVRHMYRIYG LQLLMEDTWK RIRFPDILRV
   241  FWLTRVTAQA TVLMYILRMA NETDSFFISW DDFWDLICNL IISGCDSTLT VLGMSAVISS
   301  VAHYLGLGIL AFIGSTEEDD RRLGFVAPVL FFILALQTGL SGLRPEERLI RLSRNMCLLL
   361  TAVLHFIHGM TDPVLMSLSA SHVSSFRRHF PVLFVSACLF ILPVLLSYVL WHHYALNTWL
   421  FAVTAFCVEL CLKVIVSLTV YTLFMIDGYY NVLWEKLDDY VYYVRSTGSI IEFIFGVVMF
   481  GNGAYTMMFE SGSKIRAFMM CLHAYFNIYL QAKNGWKTFM NRRTAVKKIN SLPEIKGSRL
   541  QEINDVCAIC YHEFTTSARI TPCNHYFHAL CLRKWLYIQD TCPMCHQKVY IEDDIKDNSN
   601  VSNNNGFIPP NETPEEAVRE AAAESDRELN EDDSTDCDDD VQRERNGVIQ HTGAAAEEFN
   661  DDTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF139 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 88 nTPM
  • testis: 64 nTPM
  • liver: 24 nTPM
  • adipose tissue: 22 nTPM
  • ovary: 22 nTPM
  • tongue: 21 nTPM

Single-cell type

  • late spermatids: 1,595 nCPM
  • early spermatids: 965 nCPM
  • late primary spermatocytes: 277 nCPM
  • syncytiotrophoblasts: 101 nCPM
  • neutrophils: 97 nCPM
  • extravillous trophoblasts: 85 nCPM

Immune cell

  • non-classical monocyte: 12 nTPM
  • T-reg: 11 nTPM
  • MAIT T-cell: 11 nTPM
  • memory CD8 T-cell: 11 nTPM
  • eosinophil: 10 nTPM
  • gdT-cell: 8.7 nTPM

Brain region

  • cerebellum: 28 nTPM
  • white matter: 27 nTPM
  • cerebral cortex: 23 nTPM
  • spinal cord: 22 nTPM
  • hypothalamus: 21 nTPM
  • medulla oblongata: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF139.

Disease | AllUniProt

Conditions RNF139 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.54
gnomAD missense Z
1.84
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF139 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF139 as an antibody target. Whether an autoantibody or antibody against RNF139 could matter depends on whether native RNF139 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF139 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF139 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF139. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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