Seroatlas · Human Serome Atlas

DACT3

Dapper homolog 3

Also known as: DACT3_HUMAN, DAPPER3, MGC15476, RRR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96B18
Gene: DACT3
Ensembl: ENSG00000197380
Chromosome: 19
Canonical length: 629 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cell growth. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

629 residues, UniProt reviewed canonical sequence.

>Q96B18|DACT3
     1  MIRAFSFPVS PERGRLRGWL EGSLAGLCEL HWLRERQEYR VQQALRLAQP GMGGAEAEDE
    61  EDADEDEDAA AARRAAAALE EQLEALPGLV WDLGQQLGDL SLESGGLEQE SGRSSGFYED
   121  PSSTGGPDSP PSTFCGDSGF SGSSSYGRLG PSEPRGIYAS ERPKSLGDAS PSAPEVVGAR
   181  AAVPRSFSAP YPTAGGSAGP EACSSAERRA RAGPFLTPSP LHAVAMRSPR PCGRPPTDSP
   241  DAGGAGRPLD GYISALLRRR RRRGAGQPRT SPGGADGGPR RQNSVRQRPP DASPSPGSAR
   301  PAREPSLERV GGHPTSPAAL SRAWASSWES EAAPEPAAPP AAPSPPDSPA EGRLVKAQYI
   361  PGAQAATRGL PGRAARRKPP PLTRGRSVEQ SPPRERPRAA GRRGRMAEAS GRRGSPRARK
   421  ASRSQSETSL LGRASAVPSG PPKYPTAERE EPRPPRPRRG PAPTLAAQAA GSCRRWRSTA
   481  EIDAADGRRV RPRAPAARVP GPGPSPSAPQ RRLLYGCAGS DSECSAGRLG PLGRRGPAGG
   541  VGGGYGESES SASEGESPAF SSASSDSDGS GGLVWPQQLV AATAASGGGA GAGAPAGPAK
   601  VFVKIKASHA LKKKILRFRS GSLKVMTTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DACT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 119 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 119 nTPM
cerebral cortex: 64 nTPM
hippocampal formation: 55 nTPM
colon: 51 nTPM
amygdala: 51 nTPM
spinal cord: 47 nTPM

Single-cell type

vascular smooth muscle cells: 73 nCPM
smooth muscle cells: 58 nCPM
oligodendrocytes: 39 nCPM
early spermatids: 30 nCPM
bergmann glia: 27 nCPM
oligodendrocyte progenitor cells: 24 nCPM

Immune cell

basophil: 2.4 nTPM
neutrophil: 1.6 nTPM
NK-cell: 0.7 nTPM
naive B-cell: 0.4 nTPM
classical monocyte: 0.3 nTPM
eosinophil: 0.3 nTPM

Brain region

white matter: 127 nTPM
cerebral cortex: 123 nTPM
thalamus: 108 nTPM
medulla oblongata: 107 nTPM
hippocampal formation: 105 nTPM
amygdala: 99 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.51
gnomAD missense Z: 2.01
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DACT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DACT3 as an antibody target. Whether an autoantibody or antibody against DACT3 could matter depends on whether native DACT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DACT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DACT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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