Seroatlas · Human Serome Atlas

NKD1

Protein naked cuticle homolog 1

Also known as: NKD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969G9
Gene: NKD1
Ensembl: ENSG00000140807
Chromosome: 16
Canonical length: 470 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

Canonical amino-acid sequenceUniProt

470 residues, UniProt reviewed canonical sequence.

>Q969G9|NKD1
     1  MGKLHSKPAA VCKRRESPEG DSFAVSAAWA RKGIEEWIGR QRCPGGVSGP RQLRLAGTIG
    61  RSTRELVGDV LRDTLSEEEE DDFRLEVALP PEKTDGLGSG DEKKMERVSE PCPGSKKQLK
   121  FEELQCDVSM EEDSRQEWTF TLYDFDNNGK VTREDITSLL HTIYEVVDSS VNHSPTSSKM
   181  LRVKLTVAPD GSQSKRSVLV NQADLQSARP RAETKPTEDL RSWEKKQRAP LRFQGDSRLE
   241  QSGCYHHCVD ENIERRNHYL DLAGIENYTS QFGPGSPSVA QKSELPPRTS NPTRSRSHEP
   301  EAIHIPHRKP QGVDPASFHF LDTPIAKVSE LQQRLRGTQD GSKHFVRSPK AQGKSVGVGH
   361  VARGARNKPP LGPAIPAVSP SAHLAASPAL LPSLAPLGHK KHKHRAKESQ QGCRGLQAPL
   421  ASGGPVLGRE HLRELPALVV YESQAGQPVQ RHEHHHHHEH HHHYHHFYQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 15 nTPM
lung: 6.5 nTPM
spinal cord: 5.8 nTPM
smooth muscle: 5.3 nTPM
endometrium: 4.8 nTPM
colon: 4.5 nTPM

Single-cell type

podocytes: 438 nCPM
oligodendrocyte progenitor cells: 96 nCPM
vascular smooth muscle cells: 80 nCPM
paneth cells: 58 nCPM
epididymal efferent duct absorptive cells: 54 nCPM
oligodendrocytes: 53 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 33 nTPM
midbrain: 28 nTPM
medulla oblongata: 21 nTPM
basal ganglia: 17 nTPM
amygdala: 17 nTPM
white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.99
gnomAD missense Z: 0.83
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NKD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKD1 as an antibody target. Whether an autoantibody or antibody against NKD1 could matter depends on whether native NKD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKD1 is annotated at the cell surface, where native NKD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NKD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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