ARR3

Protein identityUniProt · HPA

UniProt accession

P36575

Gene

ARR3

Ensembl

ENSG00000120500

Chromosome

X

Canonical length

388 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Golgi apparatus,Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>P36575|ARR3
     1  MSKVFKKTSS NGKLSIYLGK RDFVDHVDTV EPIDGVVLVD PEYLKCRKLF VMLTCAFRYG
    61  RDDLEVIGLT FRKDLYVQTL QVVPAESSSP QGPLTVLQER LLHKLGDNAY PFTLQMVTNL
   121  PCSVTLQPGP EDAGKPCGID FEVKSFCAEN PEETVSKRDY VRLVVRKVQF APPEAGPGPS
   181  AQTIRRFLLS AQPLQLQAWM DREVHYHGEP ISVNVSINNC TNKVIKKIKI SVDQITDVVL
   241  YSLDKYTKTV FIQEFTETVA ANSSFSQSFA VTPILAASCQ KRGLALDGKL KHEDTNLASS
   301  TIIRPGMDKE LLGILVSYKV RVNLMVSCGG ILGDLTASDV GVELPLVLIH PKPSHEAASS
   361  EDIVIEEFTR KGEEESQKAV EAEGDEGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

358 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARR3.

Disease | AllUniProt

Conditions ARR3 is implicated in, by any mechanism.

• Myopia 26, X-linked, female-limited (MYP26) MIM:301010

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 127 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Myopia 26, X-linked, female-limited
• ARR3-related disorder
• Inborn genetic diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.59

gnomAD pLI

0.1

gnomAD missense Z

0.57

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled receptor internalization
• signal transduction
• visual perception

Molecular functions

• G protein-coupled receptor binding
• opsin binding
• phosphoprotein binding

Cellular components

• cytoplasm
• photoreceptor inner segment
• photoreceptor outer segment
• synapse

Protein domainsUniProt · Pfam · InterPro

• Arrestin
• Arrestin-like, N-terminal
• Arrestin-like, C-terminal domain
• Arrestin-like, C-terminal domain superfamily
• Arrestin, N-terminal
• Immunoglobulin E-set
• Arrestin, conserved site
• Arrestin (or S-antigen), N-terminal domain
• Arrestin (or S-antigen), C-terminal domain

KeywordsUniProt

• Cell projection
• Disulfide bond
• Sensory transduction
• Vision

InteractionsUniProt · HPA

Protein binding partners of ARR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CXCR4
• GPR84
• ARRB1
• DVL2
• ZNF496