Seroatlas · Human Serome Atlas

UIMC1

BRCA1-A complex subunit RAP80

Also known as: RAP80, UIMC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RL1
Gene: UIMC1
Ensembl: ENSG00000087206
Chromosome: 5
Canonical length: 719 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

719 residues, UniProt reviewed canonical sequence.

>Q96RL1|UIMC1
     1  MPRRKKKVKE VSESRNLEKK DVETTSSVSV KRKRRLEDAF IVISDSDGEE PKEENGLQKT
    61  KTKQSNRAKC LAKRKIAQMT EEEQFALALK MSEQEAREVN SQEEEEEELL RKAIAESLNS
   121  CRPSDASATR SRPLATGPSS QSHQEKTTDS GLTEGIWQLV PPSLFKGSHI SQGNEAEERE
   181  EPWDHTEKTE EEPVSGSSGS WDQSSQPVFE NVNVKSFDRC TGHSAEHTQC GKPQESTGRG
   241  SAFLKAVQGS GDTSRHCLPT LADAKGLQDT GGTVNYFWGI PFCPDGVDPN QYTKVILCQL
   301  EVYQKSLKMA QRQLLNKKGF GEPVLPRPPS LIQNECGQGE QASEKNECIS EDMGDEDKEE
   361  RQESRASDWH SKTKDFQESS IKSLKEKLLL EEEPTTSHGQ SSQGIVEETS EEGNSVPASQ
   421  SVAALTSKRS LVLMPESSAE EITVCPETQL SSSETFDLER EVSPGSRDIL DGVRIIMADK
   481  EVGNKEDAEK EVAISTFSSS NQVSCPLCDQ CFPPTKIERH AMYCNGLMEE DTVLTRRQKE
   541  AKTKSDSGTA AQTSLDIDKN EKCYLCKSLV PFREYQCHVD SCLQLAKADQ GDGPEGSGRA
   601  CSTVEGKWQQ RLKNPKEKGH SEGRLLSFLE QSEHKTSDAD IKSSETGAFR VPSPGMEEAG
   661  CSREMQSSFT RRDLNESPVK SFVSISEATD CLVDFKKQVT VQPGSRTRTK AGRGRRRKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UIMC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

testis: 59 nTPM
bone marrow: 57 nTPM
blood vessel: 35 nTPM
ovary: 33 nTPM
colon: 31 nTPM
spleen: 30 nTPM

Single-cell type

neutrophils: 411 nCPM
platelets: 312 nCPM
early primary spermatocytes: 200 nCPM
cardiomyocytes: 184 nCPM
myonuclei: 171 nCPM
neutrophil progenitors: 164 nCPM

Immune cell

neutrophil: 65 nTPM
eosinophil: 33 nTPM
basophil: 16 nTPM
T-reg: 15 nTPM
NK-cell: 15 nTPM
naive B-cell: 14 nTPM

Brain region

cerebellum: 42 nTPM
choroid plexus: 35 nTPM
cerebral cortex: 33 nTPM
white matter: 32 nTPM
basal ganglia: 29 nTPM
amygdala: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin interacting motif
Rad18, zinc finger UBZ4-type
BRCA1-A complex subunit RAP80
RAP80, N-terminal
RAP80 N-terminal ubiquitin interaction motif

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UIMC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UIMC1 as an antibody target. Whether an autoantibody or antibody against UIMC1 could matter depends on whether native UIMC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UIMC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UIMC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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