Seroatlas · Human Serome Atlas

CSNK1E

Casein kinase I isoform epsilon

Also known as: CKIE, CKIepsilon, HCKIE, KC1E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49674
Gene
CSNK1E
Ensembl
ENSG00000213923
Chromosome
22
Canonical length
416 aa
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>P49674|CSNK1E
     1  MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH IESKFYKMMQ
    61  GGVGIPSIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
   121  SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
   181  SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
   241  CKGYPSEFST YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGAARN
   301  PEDVDRERRE HEREERMGQL RGSATRALPP GPPTGATANR LRSAAEPVAS TPASRIQPAG
   361  NTSPRAISRV DRERKVSMRL HRGAPANVSS SDLTGRQEVS RIPASQTSVP FDHLGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK1E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
112 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 112 nTPM
  • skin: 105 nTPM
  • lung: 98 nTPM
  • vagina: 96 nTPM
  • cerebellum: 94 nTPM
  • breast: 92 nTPM

Single-cell type

  • bergmann glia: 117 nCPM
  • oligodendrocyte progenitor cells: 101 nCPM
  • ocular epithelial cells: 94 nCPM
  • astrocytes: 79 nCPM
  • esophageal apical cells: 75 nCPM
  • adrenal medulla cells: 75 nCPM

Immune cell

  • plasmacytoid DC: 14 nTPM
  • NK-cell: 5.4 nTPM
  • MAIT T-cell: 4.3 nTPM
  • eosinophil: 4 nTPM
  • basophil: 3.9 nTPM
  • neutrophil: 3.7 nTPM

Brain region

  • white matter: 156 nTPM
  • cerebral cortex: 152 nTPM
  • thalamus: 138 nTPM
  • basal ganglia: 135 nTPM
  • amygdala: 133 nTPM
  • cerebellum: 132 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CSNK1E.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 55 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
3.18

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSNK1E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK1E as an antibody target. Whether an autoantibody or antibody against CSNK1E could matter depends on whether native CSNK1E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK1E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSNK1E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSNK1E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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