Seroatlas · Human Serome Atlas

TJAP1

Tight junction-associated protein 1

Also known as: PILT, TJAP1_HUMAN, TJP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JTD0
Gene: TJAP1
Ensembl: ENSG00000137221
Chromosome: 6
Canonical length: 557 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>Q5JTD0|TJAP1
     1  MTSAAPAKKP YRKAPPEHRE LRLEIPGSRL EQEEPLTDAE RMKLLQEENE ELRRRLASAT
    61  RRTEALEREL EIGQDCLELE LGQSREELDK FKDKFRRLQN SYTASQRTNQ ELEDKLHTLA
   121  SLSHSWIFAI KKAEMDRKTL DWEIVELTNK LLDAKNTINK LEELNERYRL DCNLAVQLLK
   181  CNKSHFRNHK FADLPCELQD MVRKHLHSGQ EAASPGPAPS LAPGAVVPTS VIARVLEKPE
   241  SLLLNSAQSG SAGRPLAEDV FVHVDMSEGV PGDPASPPAP GSPTPQPNGE CHSLGTARGS
   301  PEEELPLPAF EKLNPYPTPS PPHPLYPGRR VIEFSEDKVR IPRNSPLPNC TYATRQAISL
   361  SLVEEGSERA RPSPVPSTPA SAQASPHHQP SPAPLTLSAP ASSASSEEDL LVSWQRAFVD
   421  RTPPPAAVAQ RTAFGRDALP ELQRHFAHSP ADRDEVVQAP SARPEESELL LPTEPDSGFP
   481  REEEELNLPI SPEEERQSLL PINRGTEEGP GTSHTEGRAW PLPSSSRPQR SPKRMGVHHL
   541  HRKDSLTQAQ EQGNLLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TJAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 42 nTPM
spinal cord: 37 nTPM
ovary: 36 nTPM
pancreas: 32 nTPM
spleen: 31 nTPM
adrenal gland: 30 nTPM

Single-cell type

oligodendrocytes: 121 nCPM
adrenal cortex cells: 38 nCPM
sertoli cells: 37 nCPM
myonuclei: 36 nCPM
cytotrophoblasts: 30 nCPM
oligodendrocyte progenitor cells: 29 nCPM

Immune cell

basophil: 13 nTPM
MAIT T-cell: 9.2 nTPM
intermediate monocyte: 8.2 nTPM
non-classical monocyte: 7.5 nTPM
naive CD8 T-cell: 7.2 nTPM
classical monocyte: 7.1 nTPM

Brain region

white matter: 77 nTPM
basal ganglia: 54 nTPM
thalamus: 51 nTPM
cerebral cortex: 50 nTPM
medulla oblongata: 49 nTPM
midbrain: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

Junction-associated protein Tjap1/BEGAIN
Tight junction-associated protein 1 domain
Protein incorporated later into Tight Junctions

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TJAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TJAP1 as an antibody target. Whether an autoantibody or antibody against TJAP1 could matter depends on whether native TJAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TJAP1 is annotated at the cell surface, where native TJAP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TJAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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