Seroatlas · Human Serome Atlas

DLGAP2

Disks large-associated protein 2

Also known as: C8orf68, DAP-2, DLGP2_HUMAN, ERICH1-AS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P1A6
Gene
DLGAP2
Ensembl
ENSG00000198010
Chromosome
8
Canonical length
1054 aa
Protein class
Nuclear receptors, Predicted intracellular proteins

OverviewNCBI Gene

The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

1054 residues, UniProt reviewed canonical sequence.

>Q9P1A6|DLGAP2
     1  MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEAGD LVQPGISFPG PAEEDLDPQY
    61  SWSPTQHFNE ERYSPAPRSM KGLSGSRTQP PLCSGHTCGL APPEDCEHLH HGPDARPPYL
   121  LSPADSCPGG RHRCSPRSSV HSECVMMPVV LGDHVSSSTF PRMHYSSHYD TRDDCAVAHA
   181  GAKINRIPAN LLDQFEKQLP LHRDGFHTLQ YQRTSAAAEQ RSESPGRIRH LVHSVQKLFT
   241  KSHSLEGSSK SNANGTKADG RADDHHHAHH AKHSKRSKSK ERKPEGKPRP GMSSWWSSDD
   301  NLDSDSTYRT PSVLNRHHLG PVAHCYPDAL QSPFGDLSLK TSKSNNDVKC SACEGLALTP
   361  DAKYLKRSSW STLTVSQAKE AYRKSSLNLD KPLLHQDAKP ALRPCHYLQV PQDEWGGYPT
   421  GGKDEEIPCR RMRSGSYIKA MGDEESGESD SSPKTSPKSA ILPEPLLKSI GQRPLGEHQT
   481  QTYLQAASDV PVGHSLDPAA NYNSPKFRSR NQSYMRAVST LSQASCVSQV SEAEINGQFE
   541  SVCESVFSEV ESQAMDALDL PGCFRTRSHS YLRAIQAGYS QDDECIPMMT PSDITSTIRS
   601  TAAVSYTNYK KTPPPVPPRT TSKPLISVTA QSSTESTQDA YQDSRAQRMS PWPQDSRGLY
   661  NSTDSLDSNK AMNLALETAA AQRHLPESQS SSVRTSDKAI LVSKAEELLK SRCSSIGIQD
   721  SEFPEHQPYP RSDVETATDS DTESRGLREY HSVGVQVEDE KRHGRFKRSN SVTAAVQADL
   781  ELEGFPGHIT TEDKGLQFGS SFQRHSEPST PTQYSAVRTV RTQGLFSYRE DYRTQVDTST
   841  LPPPDPWLEP AIDTVETGRM SPCRRDGSWF LKLLHAETKR MEGWCKEMER EAEENDLSEE
   901  ILGKIRSAVG SAQLLMSQKF QQFYWLCQQN MDPSAMPRPT SQDLAGYWDM LQLSIEDVSM
   961  KFDELQRLRL NDWKMMESPE RKEERKVPPP IPKKPPKGKF PITREKSLDL PDRQRQEARR
  1021  RLMAAKRAAS FRQNSASERA DSIEIYIPEA QTRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLGAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • cerebral cortex: 6.1 nTPM
  • basal ganglia: 4.1 nTPM
  • hippocampal formation: 2.6 nTPM
  • amygdala: 2.5 nTPM
  • pituitary gland: 2.4 nTPM

Single-cell type

  • brain inhibitory neurons: 871 nCPM
  • brain excitatory neurons: 864 nCPM
  • other brain neurons: 390 nCPM
  • bergmann glia: 277 nCPM
  • late spermatids: 118 nCPM
  • late primary spermatocytes: 80 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 29 nTPM
  • basal ganglia: 20 nTPM
  • white matter: 19 nTPM
  • hippocampal formation: 18 nTPM
  • amygdala: 15 nTPM
  • hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
-1
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLGAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLGAP2 as an antibody target. Whether an autoantibody or antibody against DLGAP2 could matter depends on whether native DLGAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLGAP2 is annotated at the cell surface, where native DLGAP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DLGAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLGAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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