Seroatlas · Human Serome Atlas

LRRC1

Leucine-rich repeat-containing protein 1

Also known as: dJ523E19.1, FLJ10775, FLJ11834, LANO, LRRC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTT6
Gene: LRRC1
Ensembl: ENSG00000137269
Chromosome: 6
Canonical length: 524 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>Q9BTT6|LRRC1
     1  MFHCIPLWRC NRHVESIDKR HCSLVYVPEE IYRYARSLEE LLLDANQLRE LPEQFFQLVK
    61  LRKLGLSDNE IQRLPPEIAN FMQLVELDVS RNEIPEIPES ISFCKALQVA DFSGNPLTRL
   121  PESFPELQNL TCLSVNDISL QSLPENIGNL YNLASLELRE NLLTYLPDSL TQLRRLEELD
   181  LGNNEIYNLP ESIGALLHLK DLWLDGNQLS ELPQEIGNLK NLLCLDVSEN RLERLPEEIS
   241  GLTSLTDLVI SQNLLETIPD GIGKLKKLSI LKVDQNRLTQ LPEAVGECES LTELVLTENQ
   301  LLTLPKSIGK LKKLSNLNAD RNKLVSLPKE IGGCCSLTVF CVRDNRLTRI PAEVSQATEL
   361  HVLDVAGNRL LHLPLSLTAL KLKALWLSDN QSQPLLTFQT DTDYTTGEKI LTCVLLPQLP
   421  SEPTCQENLP RCGALENLVN DVSDEAWNER AVNRVSAIRF VEDEKDEEDN ETRTLLRRAT
   481  PHPGELKHMK KTVENLRNDM NAAKGLDSNK NEVNHAIDRV TTSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

colon: 24 nTPM
rectum: 24 nTPM
skin: 22 nTPM
parathyroid gland: 21 nTPM
esophagus: 17 nTPM
vagina: 17 nTPM

Single-cell type

pituicytes/fscs: 255 nCPM
lymphatic endothelial cells: 246 nCPM
alveolar cells type 1: 245 nCPM
endometrial glandular cells: 237 nCPM
choroid plexus epithelial cells: 217 nCPM
oligodendrocytes: 211 nCPM

Immune cell

NK-cell: 0.7 nTPM
naive B-cell: 0.5 nTPM
myeloid DC: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

white matter: 43 nTPM
medulla oblongata: 24 nTPM
choroid plexus: 23 nTPM
basal ganglia: 23 nTPM
pons: 22 nTPM
cerebral cortex: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.93
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC1 as an antibody target. Whether an autoantibody or antibody against LRRC1 could matter depends on whether native LRRC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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