Seroatlas · Human Serome Atlas

DLGAP4

Disks large-associated protein 4

Also known as: DAP4, DLGP4_HUMAN, KIAA0964, SAPAP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2H0
Gene
DLGAP4
Ensembl
ENSG00000080845
Chromosome
20
Canonical length
992 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Focal adhesion sites

OverviewNCBI Gene

The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

992 residues, UniProt reviewed canonical sequence.

>Q9Y2H0|DLGAP4
     1  MKGLGDSRPR HLSDSLDPPH EPLFAGTDRN PYLLSPTEAF AREARFPGQN TLPGDGLFPL
    61  NNQLPPPSST FPRIHYNSHF EVPEESPFPS HAQATKINRL PANLLDQFEK QLPIHRDGFS
   121  TLQFPRGEAK ARGESPGRIR HLVHSVQRLF FTKAPSLEGT AGKVGGNGSK KGGMEDGKGR
   181  RAKSKERAKA GEPKRRSRSN ISGWWSSDDN LDGEAGAFRS SGPASGLMTL GRQAERSQPR
   241  YFMHAYNTIS GHMLKTTKNN TTELTAPPPP PAPPATCPSL GVGTDTNYVK RGSWSTLTLS
   301  HAHEVCQKTS ATLDKSLLKS KSCHQGLAYH YLQVPGGGGE WSTTLLSPRE TDAAAEGPIP
   361  CRRMRSGSYI KAMGDEDSDE SGGSPKPSPK TAARRQSYLR ATQQSLGEQS NPRRSLDRLD
   421  SVDMLLPSKC PSWEEDYTPV SDSLNDSSCI SQIFGQASLI PQLFGHEQQV REAELSDQYE
   481  AACESACSEA ESTAAETLDL PLPSYFRSRS HSYLRAIQAG CSQEEDSVSL QSLSPPPSTG
   541  SLSNSRTLPS SSCLVAYKKT PPPVPPRTTS KPFISVTVQS STESAQDTYL DSQDHKSEVT
   601  SQSGLSNSSD SLDSSTRPPS VTRGGVAPAP EAPEPPPKHA ALKSEQGTLT SSESHPEAAP
   661  KRKLSSIGIQ VDCIQPVPKE EPSPATKFQS IGVQVEDDWR SSVPSHSMSS RRDTDSDTQD
   721  ANDSSCKSSE RSLPDCTPHP NSISIDAGPR QAPKIAQIKR NLSYGDNSDP ALEASSLPPP
   781  DPWLETSSSS PAEPAQPGAC RRDGYWFLKL LQAETERLEG WCCQMDKETK ENNLSEEVLG
   841  KVLSAVGSAQ LLMSQKFQQF RGLCEQNLNP DANPRPTAQD LAGFWDLLQL SIEDISMKFD
   901  ELYHLKANSW QLVETPEKRK EEKKPPPPVP KKPAKSKPAV SRDKASDASD KQRQEARKRL
   961  LAAKRAASVR QNSATESADS IEIYVPEAQT RL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLGAP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
125 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 125 nTPM
  • blood vessel: 101 nTPM
  • skin: 83 nTPM
  • colon: 68 nTPM
  • cerebral cortex: 64 nTPM
  • endometrium: 59 nTPM

Single-cell type

  • late spermatids: 303 nCPM
  • oocytes: 286 nCPM
  • retinal horizontal cells: 252 nCPM
  • myonuclei: 191 nCPM
  • retinal ganglion cells: 189 nCPM
  • retinal amacrine cells: 188 nCPM

Immune cell

  • eosinophil: 27 nTPM
  • neutrophil: 24 nTPM
  • naive B-cell: 21 nTPM
  • memory B-cell: 20 nTPM
  • non-classical monocyte: 18 nTPM
  • plasmacytoid DC: 17 nTPM

Brain region

  • cerebral cortex: 140 nTPM
  • hippocampal formation: 131 nTPM
  • amygdala: 131 nTPM
  • basal ganglia: 113 nTPM
  • thalamus: 111 nTPM
  • white matter: 89 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
2.76
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLGAP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLGAP4 as an antibody target. Whether an autoantibody or antibody against DLGAP4 could matter depends on whether native DLGAP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLGAP4 is annotated at the cell surface, where native DLGAP4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DLGAP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLGAP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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