Seroatlas · Human Serome Atlas

MAPK12

Mitogen-activated protein kinase 12

Also known as: ERK6, MK12_HUMAN, p38gamma, PRKM12, SAPK-3, SAPK3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53778
Gene
MAPK12
Ensembl
ENSG00000188130
Chromosome
22
Canonical length
367 aa
Protein class
Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>P53778|MAPK12
     1  MSSPPPARSG FYRQEVTKTA WEVRAVYRDL QPVGSGAYGA VCSAVDGRTG AKVAIKKLYR
    61  PFQSELFAKR AYRELRLLKH MRHENVIGLL DVFTPDETLD DFTDFYLVMP FMGTDLGKLM
   121  KHEKLGEDRI QFLVYQMLKG LRYIHAAGII HRDLKPGNLA VNEDCELKIL DFGLARQADS
   181  EMTGYVVTRW YRAPEVILNW MRYTQTVDIW SVGCIMAEMI TGKTLFKGSD HLDQLKEIMK
   241  VTGTPPAEFV QRLQSDEAKN YMKGLPELEK KDFASILTNA SPLAVNLLEK MLVLDAEQRV
   301  TAGEALAHPY FESLHDTEDE PQVQKYDDSF DDVDRTLDEW KRVTYKEVLS FKPPRQLGAR
   361  VSKETPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPK12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
280 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 280 nTPM
  • tongue: 113 nTPM
  • cerebellum: 30 nTPM
  • pituitary gland: 26 nTPM
  • cerebral cortex: 20 nTPM
  • endometrium: 19 nTPM

Single-cell type

  • epididymal principal cells: 34 nCPM
  • astrocytes: 32 nCPM
  • thymic myoid cells: 27 nCPM
  • gonadotrophs: 26 nCPM
  • myonuclei: 25 nCPM
  • vascular endothelial cells: 19 nCPM

Immune cell

  • NK-cell: 0.6 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • medulla oblongata: 20 nTPM
  • hypothalamus: 19 nTPM
  • cerebral cortex: 18 nTPM
  • basal ganglia: 17 nTPM
  • amygdala: 17 nTPM
  • cerebellum: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
-0.47
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPK12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPK12 as an antibody target. Whether an autoantibody or antibody against MAPK12 could matter depends on whether native MAPK12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPK12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAPK12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAPK12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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