Seroatlas · Human Serome Atlas

LIN7C

Protein lin-7 homolog C

Also known as: FLJ11215, LIN-7-C, LIN-7C, LIN7C_HUMAN, MALS-3, VELI3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUP9
Gene: LIN7C
Ensembl: ENSG00000148943
Chromosome: 11
Canonical length: 197 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables L27 domain binding activity and cytoskeletal protein binding activity. Involved in morphogenesis of an epithelial sheet. Located in cell-cell junction; cytoplasm; and plasma membrane. Part of MPP7-DLG1-LIN7 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q9NUP9|LIN7C
     1  MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV REVYEHVYET
    61  VDISSSPEVR ANATAKATVA AFAASEGHSH PRVVELPKTE EGLGFNIMGG KEQNSPIYIS
   121  RIIPGGIADR HGGLKRGDQL LSVNGVSVEG EHHEKAVELL KAAQGKVKLV VRYTPKVLEE
   181  MESRFEKMRS AKRRQQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIN7C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

liver: 23 nTPM
cerebellum: 21 nTPM
bone marrow: 15 nTPM
thyroid gland: 13 nTPM
kidney: 11 nTPM
skin: 11 nTPM

Single-cell type

parietal cells: 80 nCPM
hepatocytes: 78 nCPM
gastric chief cells: 71 nCPM
mucous neck cells: 60 nCPM
suprabasal keratinocytes: 59 nCPM
esophageal suprabasal cells: 58 nCPM

Immune cell

basophil: 17 nTPM
non-classical monocyte: 10 nTPM
eosinophil: 9.6 nTPM
naive CD4 T-cell: 9.4 nTPM
MAIT T-cell: 9 nTPM
intermediate monocyte: 8.5 nTPM

Brain region

cerebellum: 74 nTPM
hypothalamus: 36 nTPM
midbrain: 35 nTPM
cerebral cortex: 33 nTPM
hippocampal formation: 33 nTPM
spinal cord: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0.05
gnomAD missense Z: 1.09
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIN7C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIN7C as an antibody target. Whether an autoantibody or antibody against LIN7C could matter depends on whether native LIN7C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIN7C is annotated at the cell surface, where native LIN7C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LIN7C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...