Seroatlas · Human Serome Atlas

NIP7

60S ribosome subunit biogenesis protein NIP7 homolog

Also known as: CGI-37, FLJ10296, HSPC031, KD93, NIP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y221
Gene
NIP7
Ensembl
ENSG00000132603
Chromosome
16
Canonical length
180 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>Q9Y221|NIP7
     1  MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEK IMKLAANISG
    61  DKLVSLGTCF GKFTKTHKFR LHVTALDYLA PYAKYKVWIK PGAEQSFLYG NHVLKSGLGR
   121  ITENTSQYQG VVVYSMADIP LGFGVAAKST QDCRKVDPMA IVVFHQADIG EYVRHEETLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 25 nTPM
  • bone marrow: 25 nTPM
  • urinary bladder: 23 nTPM
  • lymph node: 22 nTPM
  • thymus: 20 nTPM
  • esophagus: 19 nTPM

Single-cell type

  • esophageal basal cells: 78 nCPM
  • gastric progenitor cells: 72 nCPM
  • esophageal suprabasal cells: 60 nCPM
  • oocytes: 60 nCPM
  • late primary spermatocytes: 58 nCPM
  • differentiating spermatogonia: 56 nCPM

Immune cell

  • memory CD8 T-cell: 33 nTPM
  • naive CD8 T-cell: 30 nTPM
  • MAIT T-cell: 30 nTPM
  • T-reg: 29 nTPM
  • memory B-cell: 29 nTPM
  • gdT-cell: 28 nTPM

Brain region

  • choroid plexus: 13 nTPM
  • white matter: 9.9 nTPM
  • thalamus: 9.8 nTPM
  • pons: 9.6 nTPM
  • cerebral cortex: 9 nTPM
  • hippocampal formation: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.36
gnomAD missense Z
0.19
DepMap mean gene effect
-1.97
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • PUA domain
  • PUA-like superfamily
  • PUA domain superfamily
  • UPF0113, PUA domain
  • Ribosome biogenesis factor, NIP7
  • 60S ribosome subunit biogenesis protein NIP7, pre-PUA domain
  • 60S ribosome subunit biogenesis protein Nip7, pre-PUA domain, eukaryotes
  • UPF0113 PUA domain
  • NIP7/UPF0113, pre-PUA domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NIP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIP7 as an antibody target. Whether an autoantibody or antibody against NIP7 could matter depends on whether native NIP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NIP7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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