Seroatlas · Human Serome Atlas

CNOT10

CCR4-NOT transcription complex subunit 10

Also known as: CNO10_HUMAN, FLJ12890, FLJ13165

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9A5
Gene: CNOT10
Ensembl: ENSG00000182973
Chromosome: 3
Canonical length: 744 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to be involved in mRNA catabolic process and negative regulation of translation. Located in membrane. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

744 residues, UniProt reviewed canonical sequence.

>Q9H9A5|CNOT10
     1  MAADKPADQG AEKHEGTGQS SGITDQEKEL STNAFQAFTS GNYDACLQHL ACLQDINKDD
    61  YKIILNTAVA EFFKSNQTTT DNLRQTLNQL KNQVHSAVEE MDGLDDVENS MLYYNQAVIL
   121  YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA VCFLLVDLYI LTYQAEKALH LLAVLEKMIS
   181  QGNNNKNGKN ETGNNNNKDG SNHKAESGAL IEAAKSKIHQ YKVRAYIQMK SLKACKREIK
   241  SVMNTAGNSA PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
   301  CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGSTDPGKK FSGRPMCTLL TNKRYELLYN
   361  CGIQLLHIGR PLAAFECLIE AVQVYHANPR LWLRLAECCI AANKGTSEQE TKGLPSKKGI
   421  VQSIVGQGYH RKIVLASQSI QNTVYNDGQS SAIPVASMEF AAICLRNALL LLPEEQQDPK
   481  QENGAKNSNQ LGGNTESSES SETCSSKSHD GDKFIPAPPS SPLRKQELEN LKCSILACSA
   541  YVALALGDNL MALNHADKLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
   601  DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG SAYCLRSEYD
   661  KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL QIIKRNQLLP AVKTHSEVRK
   721  KPVFQPVHPI QPIQMPAFTT VQRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNOT10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

testis: 37 nTPM
thymus: 19 nTPM
bone marrow: 17 nTPM
tonsil: 16 nTPM
spleen: 14 nTPM
lymph node: 14 nTPM

Single-cell type

somatotrophs: 146 nCPM
lactotrophs: 129 nCPM
late primary spermatocytes: 123 nCPM
thyrotrophs: 116 nCPM
erythrocyte progenitors: 111 nCPM
hematopoietic stem cells: 109 nCPM

Immune cell

non-classical monocyte: 26 nTPM
basophil: 19 nTPM
memory CD4 T-cell: 19 nTPM
naive CD4 T-cell: 18 nTPM
eosinophil: 18 nTPM
naive B-cell: 17 nTPM

Brain region

cerebellum: 13 nTPM
choroid plexus: 12 nTPM
white matter: 12 nTPM
hypothalamus: 11 nTPM
basal ganglia: 10 nTPM
thalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.98
gnomAD missense Z: 1.78
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
CCR4-NOT transcription complex subunit 10

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNOT10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNOT10 as an antibody target. Whether an autoantibody or antibody against CNOT10 could matter depends on whether native CNOT10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNOT10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNOT10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...