CCR4/nocturin mRNA turnover and transcription
IPR050410
Definition
The CCR4/nocturin family is involved in various cellular processes related to mRNA turnover and general transcription regulation. Members of the family act as catalytic components of the CCR4-NOT core complex, which functions both in the nucleus as a general transcription factor and in the cytoplasm as the major mRNA deadenylase. The complex is linked to bulk mRNA degradation, miRNA-mediated repression, and translational repression during initiation. Some family members exhibit 3'-5' RNase activity with a preference for polyadenylated substrates and may also have low exonuclease activity towards single-stranded DNA. Additionally, certain proteins within the family play roles in pre-rRNA processing, circadian rhythm regulation, metabolic gene post-transcriptional control, and antiviral responses. The family's involvement in transcription and mRNA decay reflects its importance in gene expression regulation and cellular response to environmental cues.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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