Seroatlas · Human Serome Atlas

OBI1

ORC ubiquitin ligase 1

Also known as: C13orf7, FLJ13449, OBI1_HUMAN, RNF219

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5W0B1
Gene: OBI1
Ensembl: ENSG00000152193
Chromosome: 13
Canonical length: 726 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables chromatin binding activity and ubiquitin-protein transferase activity. Involved in protein autoubiquitination; protein monoubiquitination; and regulation of DNA replication. Located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

726 residues, UniProt reviewed canonical sequence.

>Q5W0B1|OBI1
     1  MAQTVQNVTL SLTLPITCHI CLGKVRQPVI CINNHVFCSI CIDLWLKNNS QCPACRVPIT
    61  PENPCKEIIG GTSESEPMLS HTVRKHLRKT RLELLHKEYE DEIDCLQKEV EELKSKNLSL
   121  ESQIKTILDP LTLVQGNQNE DKHLVTDNPS KINPETVAEW KKKLRTANEI YEKVKDDVDK
   181  LKEANKKLKL ENGGLVRENL RLKAEVDNRS PQKFGRFAVA ALQSKVEQYE RETNRLKKAL
   241  ERSDKYIEEL ESQVAQLKNS SEEKEAMNSI CQTALSADGK GSKGSEEDVV SKNQGDSARK
   301  QPGSSTSSSS HLAKPSSSRL CDTSSARQES TSKADLNCSK NKDLYQEQVE VMLDVTDTSM
   361  DTYLEREWGN KPSDCVPYKD EELYDLPAPC TPLSLSCLQL STPENRESSV VQAGGSKKHS
   421  NHLRKLVFDD FCDSSNVSNK DSSEDDISRS ENEKKSECFS SPKTGFWDCC STSYAQNLDF
   481  ESSEGNTIAN SVGEISSKLS EKSGLCLSKR LNSIRSFEMN RTRTSSEASM DAAYLDKISE
   541  LDSMMSESDN SKSPCNNGFK SLDLDGLSKS SQGSEFLEEP DKLEEKTELN LSKGSLTNDQ
   601  LENGSEWKPT SFFLLSPSDQ EMNEDFSLHS SSCPVTNEIK PPSCLFQTEF SQGILLSSSH
   661  RLFEDQRFGS SLFKMSSEMH SLHNHLQSPW STSFVPEKRN KNVNQSTKRK IQSSLSSASP
   721  SKATKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OBI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
thymus: 12 nTPM
cerebellum: 12 nTPM
tonsil: 11 nTPM
lymph node: 9.2 nTPM
retina: 8.9 nTPM

Single-cell type

undifferentiated spermatogonia: 65 nCPM
differentiating spermatogonia: 58 nCPM
megakaryocyte progenitors: 39 nCPM
erythrocyte progenitors: 37 nCPM
monocyte progenitors: 35 nCPM
tuft cells: 35 nCPM

Immune cell

NK-cell: 11 nTPM
naive CD4 T-cell: 11 nTPM
non-classical monocyte: 10 nTPM
naive CD8 T-cell: 9.9 nTPM
memory CD8 T-cell: 9.8 nTPM
T-reg: 9.7 nTPM

Brain region

hypothalamus: 15 nTPM
cerebellum: 14 nTPM
thalamus: 13 nTPM
spinal cord: 13 nTPM
midbrain: 13 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type
Zinc finger, C3HC4 type (RING finger)
ORC ubiquitin ligase 1, RING finger
ORC ubiquitin ligase 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OBI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OBI1 as an antibody target. Whether an autoantibody or antibody against OBI1 could matter depends on whether native OBI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OBI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OBI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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