Seroatlas · Human Serome Atlas

RABGGTA

Geranylgeranyl transferase type-2 subunit alpha

Also known as: PGTA_HUMAN, PTAR3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92696
Gene
RABGGTA
Ensembl
ENSG00000100949
Chromosome
14
Canonical length
567 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable small GTPase binding activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein geranylgeranylation. Predicted to be located in cytosol and plasma membrane. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

567 residues, UniProt reviewed canonical sequence.

>Q92696|RABGGTA
     1  MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE LTSQILGANP
    61  DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL RVNPKSYGTW HHRCWLLGRL
   121  PEPNWTRELE LCARFLEVDE RNFHCWDYRR FVATQAAVPP AEELAFTDSL ITRNFSNYSS
   181  WHYRSCLLPQ LHPQPDSGPQ GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD
   241  PQDALRCLHV SRDEACLTVS FSRPLLVGSR MEILLLMVDD SPLIVEWRTP DGRNRPSHVW
   301  LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ LFRCELSVEK
   361  STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY EKETLQYFQT LKAVDPMRAT
   421  YLDDLRSKFL LENSVLKMEY AEVRVLHLAH KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP
   481  ALAALRCLEV LQASDNAIES LDGVTNLPRL QELLLCNNRL QQPAVLQPLA SCPRLVLLNL
   541  QGNPLCQAVG ILEQLAELLP SVSSVLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABGGTA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 63 nTPM
  • salivary gland: 21 nTPM
  • skin: 21 nTPM
  • skeletal muscle: 21 nTPM
  • vagina: 21 nTPM
  • pancreas: 20 nTPM

Single-cell type

  • esophageal apical cells: 202 nCPM
  • esophageal suprabasal cells: 78 nCPM
  • syncytiotrophoblasts: 52 nCPM
  • undifferentiated spermatogonia: 43 nCPM
  • esophageal basal cells: 34 nCPM
  • cytotrophoblasts: 32 nCPM

Immune cell

  • intermediate monocyte: 47 nTPM
  • non-classical monocyte: 33 nTPM
  • myeloid DC: 32 nTPM
  • classical monocyte: 26 nTPM
  • total PBMC: 18 nTPM
  • T-reg: 18 nTPM

Brain region

  • cerebral cortex: 12 nTPM
  • hypothalamus: 11 nTPM
  • medulla oblongata: 11 nTPM
  • pons: 11 nTPM
  • white matter: 10 nTPM
  • thalamus: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
0.53
DepMap mean gene effect
-1.28
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABGGTA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABGGTA as an antibody target. Whether an autoantibody or antibody against RABGGTA could matter depends on whether native RABGGTA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABGGTA is annotated at the cell surface, where native RABGGTA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RABGGTA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RABGGTA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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