Seroatlas · Human Serome Atlas

CCDC12

Coiled-coil domain-containing protein 12

Also known as: CCD12_HUMAN, MGC23918

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUD4
Gene: CCDC12
Ensembl: ENSG00000160799
Chromosome: 3
Canonical length: 166 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in nucleoplasm. Predicted to be part of U2-type spliceosomal complex and post-mRNA release spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>Q8WUD4|CCDC12
     1  MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE GEKHRELRLR
    61  NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE EVDLANLAPR KPDWDLKRDV
   121  AKKLEKLKKR TQRAIAELIR ERLKGQEDSL ASAVDAATEQ KTCDSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 78 nTPM
bone marrow: 71 nTPM
choroid plexus: 63 nTPM
lymph node: 59 nTPM
esophagus: 56 nTPM
stomach: 51 nTPM

Single-cell type

esophageal apical cells: 481 nCPM
esophageal suprabasal cells: 428 nCPM
esophageal basal cells: 239 nCPM
syncytiotrophoblasts: 232 nCPM
alveolar cells type 1: 210 nCPM
enterocytes: 205 nCPM

Immune cell

naive B-cell: 286 nTPM
memory B-cell: 276 nTPM
plasmacytoid DC: 268 nTPM
non-classical monocyte: 206 nTPM
T-reg: 196 nTPM
intermediate monocyte: 189 nTPM

Brain region

cerebellum: 29 nTPM
cerebral cortex: 29 nTPM
white matter: 27 nTPM
thalamus: 27 nTPM
spinal cord: 27 nTPM
medulla oblongata: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0.04
gnomAD missense Z: 0.42
DepMap mean gene effect: -0.37
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

mRNA splicing factor Cwf18-like
cwf18 pre-mRNA splicing factor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC12 as an antibody target. Whether an autoantibody or antibody against CCDC12 could matter depends on whether native CCDC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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