Seroatlas · Human Serome Atlas

PPP1R13B

Apoptosis-stimulating of p53 protein 1

Also known as: ASPP1, ASPP1_HUMAN, KIAA0771, p53BP2-like, p85

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KQ4
Gene: PPP1R13B
Ensembl: ENSG00000088808
Chromosome: 14
Canonical length: 1090 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1090 residues, UniProt reviewed canonical sequence.

>Q96KQ4|PPP1R13B
     1  MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR GNERPIPFDH
    61  MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ RTQRNVINVP GEKRTENGVG
   121  NPRVELTLSE LQDMAARQQQ QIENQQQMLV AKEQRLHFLK QQERRQQQSI SENEKLQKLK
   181  ERVEAQENKL KKIRAMRGQV DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ
   241  QLEDLKKGKL NGFQSYNGKL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN
   301  MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI QVPSAGSFPV
   361  LGDPIKPQSL SIASNAAHGR SKSANDGNWP TLKQNSSSSV KPVQVAGADW KDPSVEGSVK
   421  QGTVSSQPVP FSALGPTEKP GIEIGKVPPP IPGVGKQLPP SYGTYPSPTP LGPGSTSSLE
   481  RRKEGSLPRP SAGLPSRQRP TLLPATGSTP QPGSSQQIQQ RISVPPSPTY PPAGPPAFPA
   541  GDSKPELPLT VAIRPFLADK GSRPQSPRKG PQTVNSSSIY SMYLQQATPP KNYQPAAHSA
   601  LNKSVKAVYG KPVLPSGSTS PSPLPFLHGS LSTGTPQPQP PSESTEKEPE QDGPAAPADG
   661  STVESLPRPL SPTKLTPIVH SPLRYQSDAD LEALRRKLAN APRPLKKRSS ITEPEGPGGP
   721  NIQKLLYQRF NTLAGGMEGT PFYQPSPSQD FMGTLADVDN GNTNANGNLE ELPPAQPTAP
   781  LPAEPAPSSD ANDNELPSPE PEELICPQTT HQTAEPAEDN NNNVATVPTT EQIPSPVAEA
   841  PSPGEEQVPP APLPPASHPP ATSTNKRTNL KKPNSERTGH GLRVRFNPLA LLLDASLEGE
   901  FDLVQRIIYE VEDPSKPNDE GITPLHNAVC AGHHHIVKFL LDFGVNVNAA DSDGWTPLHC
   961  AASCNSVHLC KQLVESGAAI FASTISDIET AADKCEEMEE GYIQCSQFLY GVQEKLGVMN
  1021  KGVAYALWDY EAQNSDELSF HEGDALTILR RKDESETEWW WARLGDREGY VPKNLLGLYP
  1081  RIKPRQRTLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R13B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 22 nTPM
heart muscle: 21 nTPM
testis: 18 nTPM
cerebellum: 13 nTPM
ovary: 12 nTPM
skin: 11 nTPM

Single-cell type

endometrial glandular cells: 383 nCPM
prostatic hillock cells: 323 nCPM
choroid plexus epithelial cells: 320 nCPM
endometrial luminal cells: 316 nCPM
alveolar cells type 2: 304 nCPM
prostatic glandular cells: 297 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebral cortex: 33 nTPM
hippocampal formation: 31 nTPM
cerebellum: 29 nTPM
thalamus: 24 nTPM
choroid plexus: 24 nTPM
hypothalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 1
gnomAD missense Z: 1.53
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

p53 binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

SH3 domain
Ankyrin repeat
Ubiquitin-like domain superfamily
SH3-like domain superfamily
Ankyrin repeat-containing domain superfamily
Apoptosis-stimulating of p53 protein 1/2
Apoptosis-stimulating of p53 protein 2-like, RA domain
SH3 domain
Ankyrin repeats (3 copies)
Apoptosis-stimulating of p53 protein 2-like, N-terminal RA domain
Apoptosis-stimulating of p53 protein 1, RA domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R13B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R13B as an antibody target. Whether an autoantibody or antibody against PPP1R13B could matter depends on whether native PPP1R13B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R13B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R13B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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