Seroatlas · Human Serome Atlas

DAPK3

Death-associated protein kinase 3

Also known as: DAPK3_HUMAN, ZIP, ZIPK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43293
Gene
DAPK3
Ensembl
ENSG00000167657
Chromosome
19
Canonical length
454 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles,Primary cilium,Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>O43293|DAPK3
     1  MSTFRQEDVE DHYEMGEELG SGQFAIVRKC RQKGTGKEYA AKFIKKRRLS SSRRGVSREE
    61  IEREVNILRE IRHPNIITLH DIFENKTDVV LILELVSGGE LFDFLAEKES LTEDEATQFL
   121  KQILDGVHYL HSKRIAHFDL KPENIMLLDK NVPNPRIKLI DFGIAHKIEA GNEFKNIFGT
   181  PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGE TKQETLTNIS AVNYDFDEEY
   241  FSNTSELAKD FIRRLLVKDP KRRMTIAQSL EHSWIKAIRR RNVRGEDSGR KPERRRLKTT
   301  RLKEYTIKSH SSLPPNNSYA DFERFSKVLE EAAAAEEGLR ELQRSRRLCH EDVEALAAIY
   361  EEKEAWYREE SDSLGQDLRR LRQELLKTEA LKRQAQEEAK GALLGTSGLK RRFSRLENRY
   421  EALAKQVASE MRFVQDLVRA LEQEKLQGVE CGLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DAPK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 107 nTPM
  • blood vessel: 103 nTPM
  • heart muscle: 100 nTPM
  • colon: 86 nTPM
  • endometrium: 75 nTPM
  • lung: 68 nTPM

Single-cell type

  • syncytiotrophoblasts: 169 nCPM
  • extravillous trophoblasts: 133 nCPM
  • migrating cytotrophoblasts: 121 nCPM
  • basal keratinocytes: 110 nCPM
  • decidual stromal cells: 108 nCPM
  • esophageal apical cells: 94 nCPM

Immune cell

  • basophil: 33 nTPM
  • eosinophil: 33 nTPM
  • neutrophil: 30 nTPM
  • NK-cell: 24 nTPM
  • T-reg: 24 nTPM
  • gdT-cell: 23 nTPM

Brain region

  • cerebral cortex: 70 nTPM
  • choroid plexus: 52 nTPM
  • pons: 51 nTPM
  • thalamus: 48 nTPM
  • hippocampal formation: 47 nTPM
  • white matter: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.01
gnomAD missense Z
1.8
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DAPK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DAPK3 as an antibody target. Whether an autoantibody or antibody against DAPK3 could matter depends on whether native DAPK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DAPK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DAPK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DAPK3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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