Seroatlas · Human Serome Atlas

HOOK1

Protein Hook homolog 1

Also known as: HK1, HOOK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJC3
Gene
HOOK1
Ensembl
ENSG00000134709
Chromosome
1
Canonical length
728 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

728 residues, UniProt reviewed canonical sequence.

>Q9UJC3|HOOK1
     1  MEETQPPPQP KLPLCDSLMI WLQTFNTASP CQDVKQLTSG VAMAQVLHQI DAAWFNESWL
    61  SRIKEDVGDN WRIKASNVKK VLQGIMSYYH EFLGQQISEA LIPDLNQITE CSDPVELGRL
   121  LQLILGCAIN CEKKQEHIQN IMTLEESVQH VVMTAIQELM SKEILSSPPN DAVGELEQQL
   181  KRALEELQEA LAEKEELRQR CEELDMQVTT LQDEKNSLVS ENEMMNEKLD QLDGSFDDPN
   241  TVVAKKYFHA QLQLEQLQEE NFRLEAAKDD YRVHCEELEK QLIEFQHRND ELTSLAEETR
   301  ALKDEIDVLR ATSDKANKLE STVEIYRQKL QDLNDLRKQV KTLQETNMMY MHNTVSLEEE
   361  LKKANAARTQ LETYKRQVQD LHVKLSSESK RADTLAFEMK RLEEKHEALL KEKERLIEQR
   421  DTLKETNEEL RCSQVQQDHL NQTDASATKS YENLAAEIMP VEYREVFIRL QHENKMLRLQ
   481  QEGSENERIE ELQEQLEQKH RKMNELETEQ RLSKERIREL QQQIEDLQKS LQEQGSKSEG
   541  ESSSKLKQKL EAHMEKLTEV HEELQKKQEL IEDLQPDINQ NVQKINELEA ALQKKDEDMK
   601  AMEERYKMYL EKARNVIKTL DPKLNPASAE IMLLRKQLAE KERRIEILES ECKVAKFRDY
   661  EEKLIVSAWY NKSLAFQKLG MESRLVSGGG ACSDTGACTP ARSFLAQQRH ITNTRRNLSV
   721  KVPATTSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOOK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • retina: 47 nTPM
  • liver: 28 nTPM
  • parathyroid gland: 25 nTPM
  • pancreas: 17 nTPM
  • salivary gland: 16 nTPM
  • small intestine: 15 nTPM

Single-cell type

  • late spermatids: 1,305 nCPM
  • early spermatids: 786 nCPM
  • late primary spermatocytes: 189 nCPM
  • cone photoreceptor cells: 143 nCPM
  • esophageal apical cells: 138 nCPM
  • retinal bipolar cells: 138 nCPM

Immune cell

  • naive CD4 T-cell: 6.7 nTPM
  • naive CD8 T-cell: 2.4 nTPM
  • naive B-cell: 2 nTPM
  • NK-cell: 2 nTPM
  • memory CD4 T-cell: 1.8 nTPM
  • MAIT T-cell: 1.7 nTPM

Brain region

  • cerebellum: 15 nTPM
  • choroid plexus: 14 nTPM
  • cerebral cortex: 11 nTPM
  • basal ganglia: 9.7 nTPM
  • thalamus: 8.5 nTPM
  • hippocampal formation: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0
gnomAD missense Z
0.85
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HOOK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOOK1 as an antibody target. Whether an autoantibody or antibody against HOOK1 could matter depends on whether native HOOK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOOK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOOK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HOOK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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