Seroatlas · Human Serome Atlas

CCDC136

Coiled-coil domain-containing protein 136

Also known as: CC136_HUMAN, DKFZP434G156, KIAA1793, NAG6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JN2
Gene: CCDC136
Ensembl: ENSG00000128596
Chromosome: 7
Canonical length: 1154 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles,Plasma membrane,Mid piece

OverviewNCBI Gene

Predicted to be involved in acrosome assembly and single fertilization. Predicted to be located in cytoplasmic vesicle and membrane. Predicted to be active in acrosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1154 residues, UniProt reviewed canonical sequence.

>Q96JN2|CCDC136
     1  MQAMEGEVLL PALYEEEEEE EEEEEEVEEE EEQVQKGGSV GSLSVNKHRG LSLTETELEE
    61  LRAQVLQLVA ELEETRELAG QHEDDSLELQ GLLEDERLAS AQQAEVFTKQ IQQLQGELRS
   121  LREEISLLEH EKESELKEIE QELHLAQAEI QSLRQAAEDS ATEHESDIAS LQEDLCRMQN
   181  ELEDMERIRG DYEMEIASLR AEMEMKSSEP SGSLGLSDYS GLQEELQELR ERYHFLNEEY
   241  RALQESNSSL TGQLADLESE RTQRATERWL QSQTLSMTSA ESQTSEMDFL EPDPEMQLLR
   301  QQLRDAEEQM HGMKNKCQEL CCELEELQHH RQVSEEEQRR LQRELKCAQN EVLRFQTSHS
   361  VTQNEELKSR LCTLQKKYDT SQDEQNELLK MQLQLQTELR QLKVMKSTLV ENQSEKELLC
   421  RLQKLHLQHQ NVTCEKEKLL ERQQQLQEEL QCHEAELQHL RDTVASFKES NEKDTETHAQ
   481  LQEMKQLYQA SKDELERQKH MYDQLEQDLL LCQLELKELK ASHPIPEDKG KCANKCDTLL
   541  SRLTELQEKY KASQKEMGQL QMEQCELLED QRRMQEEQGQ LQEELHRLTL PLPKSGLLLK
   601  SQELLTKLED LCELQLLYQG MQEEQKKLIQ NQDCVLKEQL EIHEELRRFK ESHFQEVLEN
   661  PDDSKLAKSS KCNRNKQSKL LMEQMQALQV MYDAGQAKQE LLQQEQGRLL EERKRLQADL
   721  QLCLEEMQLL QVQSPSIKMS LESYGKSYGS MVPSNENCRK TYDTTVDDNE SYYKSYTSTQ
   781  TSSKSFLKSY DSSTSASEAY GKSYCTTSNS SITYKKSYGS TSSSDTCQKS FVSSCTDEEP
   841  AEPEDMERFE EMVVKVLIKL QAVQAMYQIS QEEHSQLQEQ MEKLLAKQKD LKEELDACER
   901  EFKECMECLE KPMAPQNDKN EIKELQTKLR ELQLQYQASM DEQGRLLVVQ EQLEGQLQCC
   961  QEELRQLREK RPSVVKEARG KNANKNMNKN ANGVKMKKVT KPCSDTSESD LETRKSLEVV
  1021  LYYKASQRKL DGLAKEEEKK EEMEEEKKQV KEEAKEQCGD ELVAEPADPE EAKSTEDQEE
  1081  NEEDKEEEEK EEDSEEEEDD ADSSLESPEE NNPLRLSESK KSSPTPNPPI FSLPLVGLVV
  1141  ISALLWCWWA ETSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC136 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 175 nTPM

Expression across tissuesHPA

Tissue

testis: 175 nTPM
cerebellum: 82 nTPM
cerebral cortex: 65 nTPM
retina: 49 nTPM
hypothalamus: 45 nTPM
midbrain: 33 nTPM

Single-cell type

late spermatids: 3,445 nCPM
late primary spermatocytes: 1,029 nCPM
early spermatids: 787 nCPM
retinal bipolar cells: 333 nCPM
retinal pigment epithelial cells: 175 nCPM
early primary spermatocytes: 93 nCPM

Immune cell

NK-cell: 0.6 nTPM
eosinophil: 0.3 nTPM
gdT-cell: 0.3 nTPM
MAIT T-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

thalamus: 184 nTPM
midbrain: 113 nTPM
cerebellum: 87 nTPM
cerebral cortex: 81 nTPM
amygdala: 77 nTPM
spinal cord: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 1.13
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

acrosomal membrane

Protein domainsUniProt · Pfam · InterPro

Centrosomal and Immune Signaling Modulators

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC136 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CDC5L

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC136 as an antibody target. Whether an autoantibody or antibody against CCDC136 could matter depends on whether native CCDC136 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC136 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC136 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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