Seroatlas · Human Serome Atlas

CWC15

Spliceosome-associated protein CWC15 homolog

Also known as: AD002, C11orf5, CWC15_HUMAN, Cwf15, HSPC148

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P013
Gene: CWC15
Ensembl: ENSG00000150316
Chromosome: 11
Canonical length: 229 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Mitochondria
Quaternary structure: Homotetramer

OverviewNCBI Gene

Predicted to enable RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in mitochondrion and nuclear speck. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q9P013|CWC15
     1  MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA PEEVRNRDFR
    61  RELEERERAA AREKNRDRPT REHTTSSSVS KKPRLDQIPA ANLDADDPLT DEEDEDFEEE
   121  SDDDDTAALL AELEKIKKER AEEQARKEQE QKAEEERIRM ENILSGNPLL NLTGPSQPQA
   181  NFKVKRRWDD DVVFKNCAKG VDDQKKDKRF VNDTLRSEFH KKFMEKYIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CWC15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 67 nTPM
tongue: 56 nTPM
spinal cord: 41 nTPM
testis: 38 nTPM
amygdala: 38 nTPM
midbrain: 37 nTPM

Single-cell type

early spermatids: 923 nCPM
late primary spermatocytes: 642 nCPM
oocytes: 553 nCPM
megakaryocytes: 272 nCPM
esophageal apical cells: 270 nCPM
esophageal suprabasal cells: 237 nCPM

Immune cell

basophil: 46 nTPM
non-classical monocyte: 36 nTPM
T-reg: 35 nTPM
eosinophil: 34 nTPM
MAIT T-cell: 32 nTPM
memory CD4 T-cell: 31 nTPM

Brain region

midbrain: 24 nTPM
hypothalamus: 23 nTPM
white matter: 22 nTPM
medulla oblongata: 21 nTPM
cerebral cortex: 21 nTPM
pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.98
gnomAD missense Z: 2.12

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Pre-mRNA-splicing factor Cwf15/Cwc15
Cwf15/Cwc15 cell cycle control protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CWC15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CWC15 as an antibody target. Whether an autoantibody or antibody against CWC15 could matter depends on whether native CWC15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CWC15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CWC15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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