Seroatlas · Human Serome Atlas

CTNNBL1

Beta-catenin-like protein 1

Also known as: C20orf33, CTBL1_HUMAN, FLJ21108, NAP, NYD-SP19, P14, P14L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WYA6
Gene
CTNNBL1
Ensembl
ENSG00000132792
Chromosome
20
Canonical length
563 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>Q8WYA6|CTNNBL1
     1  MDVGELLSYQ PNRGTKRPRD DEEEEQKMRR KQTGTRERGR YREEEMTVVE EADDDKKRLL
    61  QIIDRDGEEE EEEEEPLDES SVKKMILTFE KRSYKNQELR IKFPDNPEKF MESELDLNDI
   121  IQEMHVVATM PDLYHLLVEL NAVQSLLGLL GHDNTDVSIA VVDLLQELTD IDTLHESEEG
   181  AEVLIDALVD GQVVALLVQN LERLDESVKE EADGVHNTLA IVENMAEFRP EMCTEGAQQG
   241  LLQWLLKRLK AKMPFDANKL YCSEVLAILL QDNDENRELL GELDGIDVLL QQLSVFKRHN
   301  PSTAEEQEMM ENLFDSLCSC LMLSSNRERF LKGEGLQLMN LMLREKKISR SSALKVLDHA
   361  MIGPEGTDNC HKFVDILGLR TIFPLFMKSP RKIKKVGTTE KEHEEHVCSI LASLLRNLRG
   421  QQRTRLLNKF TENDSEKVDR LMELHFKYLG AMQVADKKIE GEKHDMVRRG EIIDNDTEEE
   481  FYLRRLDAGL FVLQHICYIM AEICNANVPQ IRQRVHQILN MRGSSIKIVR HIIKEYAENI
   541  GDGRSPEFRE NEQKRILGLL ENF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTNNBL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 51 nTPM
  • liver: 44 nTPM
  • testis: 41 nTPM
  • bone marrow: 39 nTPM
  • tonsil: 39 nTPM
  • thymus: 37 nTPM

Single-cell type

  • mast cells: 514 nCPM
  • megakaryocyte-erythroid progenitors: 461 nCPM
  • early spermatids: 411 nCPM
  • late primary spermatocytes: 279 nCPM
  • cytotrophoblasts: 218 nCPM
  • monocytes: 192 nCPM

Immune cell

  • basophil: 268 nTPM
  • myeloid DC: 110 nTPM
  • non-classical monocyte: 110 nTPM
  • eosinophil: 104 nTPM
  • intermediate monocyte: 103 nTPM
  • memory B-cell: 89 nTPM

Brain region

  • choroid plexus: 25 nTPM
  • white matter: 24 nTPM
  • cerebral cortex: 23 nTPM
  • medulla oblongata: 23 nTPM
  • basal ganglia: 23 nTPM
  • midbrain: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CTNNBL1.

Disease | AllUniProt

Conditions CTNNBL1 is implicated in, by any mechanism.

  • Immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias (IMD99) MIM:619846

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.01
gnomAD missense Z
2.18
DepMap mean gene effect
-0.9
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTNNBL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTNNBL1 as an antibody target. Whether an autoantibody or antibody against CTNNBL1 could matter depends on whether native CTNNBL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTNNBL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification.

Canonical record: https://seroatlas.com/gene/CTNNBL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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