Seroatlas · Human Serome Atlas

BAK1

Bcl-2 homologous antagonist/killer

Also known as: BAK, BAK_HUMAN, BCL2L7, CDN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16611
Gene
BAK1
Ensembl
ENSG00000030110
Chromosome
6
Canonical length
211 aa
Protein class
Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q16611|BAK1
     1  MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YRHQQEQEAE GVAAPADPEM
    61  VTLPLQPSST MGQVGRQLAI IGDDINRRYD SEFQTMLQHL QPTAENAYEY FTKIATSLFE
   121  SGINWGRVVA LLGFGYRLAL HVYQHGLTGF LGQVTRFVVD FMLHHCIARW IAQRGGWVAA
   181  LNLGNGPILN VLVVLGVVLL GQFVVRRFFK S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 44 nTPM
  • small intestine: 35 nTPM
  • esophagus: 32 nTPM
  • colon: 30 nTPM
  • spleen: 29 nTPM
  • adrenal gland: 28 nTPM

Single-cell type

  • megakaryocytes: 62 nCPM
  • enterocytes: 55 nCPM
  • colonocytes: 44 nCPM
  • esophageal basal cells: 41 nCPM
  • esophageal suprabasal cells: 40 nCPM
  • extravillous trophoblasts: 40 nCPM

Immune cell

  • eosinophil: 85 nTPM
  • intermediate monocyte: 65 nTPM
  • basophil: 64 nTPM
  • non-classical monocyte: 57 nTPM
  • T-reg: 56 nTPM
  • total PBMC: 53 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • thalamus: 14 nTPM
  • medulla oblongata: 14 nTPM
  • pons: 13 nTPM
  • spinal cord: 13 nTPM
  • cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0
gnomAD missense Z
0.99
DepMap mean gene effect
-0.37
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BAK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BAK1 as an antibody target. Whether an autoantibody or antibody against BAK1 could matter depends on whether native BAK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BAK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BAK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BAK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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