Seroatlas · Human Serome Atlas

RNF183

E3 ubiquitin-protein ligase RNF183

Also known as: MGC4734, RN183_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96D59
Gene: RNF183
Ensembl: ENSG00000165188
Chromosome: 9
Canonical length: 192 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; protein ubiquitination; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q96D59|RNF183
     1  MAEQQGRELE AECPVCWNPF NNTFHTPKML DCCHSFCVEC LAHLSLVTPA RRRLLCPLCR
    61  QPTVLASGQP VTDLPTDTAM LALLRLEPHH VILEGHQLCL KDQPKSRYFL RQPQVYTLDL
   121  GPQPGGQTGP PPDTASATVS TPILIPSHHS LRECFRNPQF RIFAYLMAVI LSVTLLLIFS
   181  IFWTKQFLWG VG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF183 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

epididymis: 15 nTPM
kidney: 9.3 nTPM
salivary gland: 6 nTPM
gallbladder: 5.4 nTPM
testis: 4.2 nTPM
esophagus: 4 nTPM

Single-cell type

epididymal principal cells: 54 nCPM
epididymal efferent duct ciliated cells: 40 nCPM
endometrial luminal cells: 40 nCPM
proximal tubule cells: 31 nCPM
esophageal apical cells: 23 nCPM
epididymal efferent duct absorptive cells: 21 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 0.6 nTPM
amygdala: 0.4 nTPM
spinal cord: 0.4 nTPM
white matter: 0.4 nTPM
basal ganglia: 0.3 nTPM
cerebellum: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF183 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF183 as an antibody target. Whether an autoantibody or antibody against RNF183 could matter depends on whether native RNF183 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF183 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF183 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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